RECRUITING

Combined Anabolic Therapy

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Conditions

Osteoporosis, PostmenopausalOsteoporosis

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

In this research study the study investigators want to learn more about the effect of two different FDA-approved medication regimens in the treatment of postmenopausal osteoporosis.

Official Title

Combined Anabolic Therapy Study

Quick Facts

Study Start:2025-02-03
Study Completion:2027-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06558188

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * women aged 45+
  2. * postmenopausal
  3. * osteoporotic with high risk of fracture
  1. * no significant previous use of bone health modifying treatments
  2. * known congenital or acquired bone disease other than osteoporosis
  3. * significant renal disease, liver disease, cardiopulmonary disease, or psychiatric disease
  4. * abnormal calcium or parathyroid hormone level
  5. * serum vitamin D \<20 ng/dL
  6. * anemia (hematocrit \<32%)
  7. * history of malignancy (except non-melanoma skin carcinoma)
  8. * excessive alcohol use or substance abuse
  9. * known contraindications to romosozumab or teriparatide

Contacts and Locations

Study Contact

Aparna Patnaik, BA
CONTACT
617-726-6129
apatnaik1@mgh.harvard.edu

Principal Investigator

Benjamin Leder, MD
PRINCIPAL_INVESTIGATOR
MGH

Study Locations (Sites)

Massachusetts General Hospital
Boston, Massachusetts, 02114
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Benjamin Leder, MD, PRINCIPAL_INVESTIGATOR, MGH

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-03
Study Completion Date2027-07-01

Study Record Updates

Study Start Date2025-02-03
Study Completion Date2027-07-01

Terms related to this study

Additional Relevant MeSH Terms

  • Osteoporosis, Postmenopausal
  • Osteoporosis