RECRUITING

A Study on TLC590 for Managing Postsurgical Pain

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This Phase 2 open-label trial investigates the pharmacokinetics (PK), pharmacodynamics, and safety profile of TLC590 across various surgical procedures. Researchers aim to determine the maximum tolerated dose (MTD) of TLC590 via Safety Monitoring Committee (SMC). The study evaluates TLC590 in bunionectomy, laparoscopy-assisted open ventral hernia repair, breast augmentation, abdominoplasty, and total knee arthroplasty models. Additionally, it determines the relative bioavailability of TLC590 to ropivacaine injection.

Official Title

A Phase 2, Open-label, Dose-escalation Study to Evaluate Pharmacokinetics, Pharmacodynamics, Bioavailability, Safety, and Tolerability of TLC590 in Multiple Surgical Models

Quick Facts

Study Start:2024-09-30

Study Completion:2026-08

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06574269

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Able and willing to provide written informed consent 2. Male or female aged 18 to 70 years, inclusive. For the Part 2 breast augmentation surgical model, only females can be enrolled 3. Scheduled to undergo one of the following elective surgeries, with no additional procedures and be able to use the anesthesia regimen: 1. Unilateral first metatarsal bunionectomy (Cohort 1) 2. Laparoscopy-assisted open ventral hernia repair (Cohort 2 and 6) 3. Breast augmentation (Cohort 3 through 5) 4. Unilateral total knee arthroplasty (Cohort 7) 5. Abdominoplasty (tummy tuck) (Cohort 8) 4. ASA Physical Status Classification of 1 or 2 5. Male subjects must be either biologically or surgically sterile or commit to the use of a reliable method of birth control (must agree to use double-barrier contraception in the event of sexual activity) or be practicing abstinence for the duration of the study and for 30 days after study drug administration 6. Female subjects are eligible only if all the following apply: 1. Not pregnant with a negative serum pregnancy test at Screening and negative urine pregnancy test on Day 1 before surgery (pregnancy test not required for females of non-childbearing potential, defined as surgically sterile or post-menopausal) 2. Not lactating 3. Not planning to become pregnant during the study 4. If of childbearing potential, commits to the use of a highly effective method of birth control for the duration of the study and or at least 30 days after study drug administration 7. BMI \>18 \~ ≤39 kg/m2	1. A clinically significant abnormal clinical laboratory test value 2. Evidence of a clinically significant 12-lead ECG 3. History of orthostatic hypotension, syncope, or other syncopal attacks 4. History or any clinical manifestation of significant renal, hepatic, gastrointestinal, cardiovascular, metabolic, neurologic, psychiatric, or other condition that has been assessed by the Investigator to be unsuitable for participation in the study 5. History of seizures or taking anticonvulsants during the Screening period 6. History of cardiac arrhythmia or taking Class III antiarrhythmic drugs including amiodarone, dofetilide, dronedarone, sotalol, or ibutilide during the Screening period 7. History of sleep apnea or on home CPAP treatment 8. History of hypersensitivity to ropivacaine, any other amide-type local anesthetic, propofol, hydromorphone, fentanyl, midazolam, acetaminophen, oxycodone, or morphine (or other opioids) 9. History of severe or refractory PONV due to other etiologies, including, but not limited to gastric outlet obstruction, hypercalcemia, or active peptic ulcer, deemed clinically significant by the Investigator 10. Any lifetime history of a suicidal attempt or any suicidal behavior, as assessed by the C-SSRS at Screening 11. History or positive test results of HIV, HCV, or HBV 12. History or current report of substance abuse including illicit drug abuse and/or alcohol abuse (regularly drinks \>4 units of alcohol per day: 1 unit = 8 oz. beer, 3 oz. wine, or 1 oz. spirits) within 2 years prior to Screening 13. Positive results on the urine drug screen or alcohol breath test indicative of illicit drug or non-prescribed drug or alcohol abuse at Screening or on Day 1 before surgery. Prescribed medication that is known to result in a positive drug test is allowed. Marijuana (medical or recreational) is not allowed 14. Pre-existing concurrent acute, or chronic painful restrictive/physical condition that may confound postoperative pain assessments or is expected to require analgesic treatment during the study 15. Has known or suspected daily use of opioids for longer than 4 days per week within the previous 6 months prior to Screening 16. Is taking daily analgesics for longer than 4 days per week for a chronically painful condition during the Screening period. Not exclusionary if it is utilized for pain related to the total knee arthroplasty indication 17. Is receiving oxygen therapy during the Screening period 18. Use of any of the following medications within 5 half-lives prior to the study surgical procedure or as specified 19. Malignancy in the last 2 years prior to Screening, except for non-metastatic basal cell or squamous cell carcinoma of the skin or localized carcinoma in situ of the cervix 20. Personal or family history of malignant hyperthermia

Inclusion Criteria

Exclusion Criteria

1. Able and willing to provide written informed consent
2. Male or female aged 18 to 70 years, inclusive. For the Part 2 breast augmentation surgical model, only females can be enrolled
3. Scheduled to undergo one of the following elective surgeries, with no additional procedures and be able to use the anesthesia regimen:
1. Unilateral first metatarsal bunionectomy (Cohort 1)
2. Laparoscopy-assisted open ventral hernia repair (Cohort 2 and 6)
3. Breast augmentation (Cohort 3 through 5)
4. Unilateral total knee arthroplasty (Cohort 7)
5. Abdominoplasty (tummy tuck) (Cohort 8)
4. ASA Physical Status Classification of 1 or 2
5. Male subjects must be either biologically or surgically sterile or commit to the use of a reliable method of birth control (must agree to use double-barrier contraception in the event of sexual activity) or be practicing abstinence for the duration of the study and for 30 days after study drug administration
6. Female subjects are eligible only if all the following apply:
1. Not pregnant with a negative serum pregnancy test at Screening and negative urine pregnancy test on Day 1 before surgery (pregnancy test not required for females of non-childbearing potential, defined as surgically sterile or post-menopausal)
2. Not lactating
3. Not planning to become pregnant during the study
4. If of childbearing potential, commits to the use of a highly effective method of birth control for the duration of the study and or at least 30 days after study drug administration
7. BMI \>18 \~ ≤39 kg/m2

1. A clinically significant abnormal clinical laboratory test value
2. Evidence of a clinically significant 12-lead ECG
3. History of orthostatic hypotension, syncope, or other syncopal attacks
4. History or any clinical manifestation of significant renal, hepatic, gastrointestinal, cardiovascular, metabolic, neurologic, psychiatric, or other condition that has been assessed by the Investigator to be unsuitable for participation in the study
5. History of seizures or taking anticonvulsants during the Screening period
6. History of cardiac arrhythmia or taking Class III antiarrhythmic drugs including amiodarone, dofetilide, dronedarone, sotalol, or ibutilide during the Screening period
7. History of sleep apnea or on home CPAP treatment
8. History of hypersensitivity to ropivacaine, any other amide-type local anesthetic, propofol, hydromorphone, fentanyl, midazolam, acetaminophen, oxycodone, or morphine (or other opioids)
9. History of severe or refractory PONV due to other etiologies, including, but not limited to gastric outlet obstruction, hypercalcemia, or active peptic ulcer, deemed clinically significant by the Investigator
10. Any lifetime history of a suicidal attempt or any suicidal behavior, as assessed by the C-SSRS at Screening
11. History or positive test results of HIV, HCV, or HBV
12. History or current report of substance abuse including illicit drug abuse and/or alcohol abuse (regularly drinks \>4 units of alcohol per day: 1 unit = 8 oz. beer, 3 oz. wine, or 1 oz. spirits) within 2 years prior to Screening
13. Positive results on the urine drug screen or alcohol breath test indicative of illicit drug or non-prescribed drug or alcohol abuse at Screening or on Day 1 before surgery. Prescribed medication that is known to result in a positive drug test is allowed. Marijuana (medical or recreational) is not allowed
14. Pre-existing concurrent acute, or chronic painful restrictive/physical condition that may confound postoperative pain assessments or is expected to require analgesic treatment during the study
15. Has known or suspected daily use of opioids for longer than 4 days per week within the previous 6 months prior to Screening
16. Is taking daily analgesics for longer than 4 days per week for a chronically painful condition during the Screening period. Not exclusionary if it is utilized for pain related to the total knee arthroplasty indication
17. Is receiving oxygen therapy during the Screening period
18. Use of any of the following medications within 5 half-lives prior to the study surgical procedure or as specified
19. Malignancy in the last 2 years prior to Screening, except for non-metastatic basal cell or squamous cell carcinoma of the skin or localized carcinoma in situ of the cervix
20. Personal or family history of malignant hyperthermia

Contacts and Locations

Study Contact

Grace Tsao

CONTACT

+886-2-26557377

grace@tlcbio.com

Principal Investigator

Tien-Tzu Tai, MD

STUDY_DIRECTOR

Taiwan Liposome Company

Study Locations (Sites)

First Surgical Hospital

Bellaire, Texas, 77401

United States

Memorial Hermann Village

Houston, Texas, 77043

United States

Collaborators and Investigators

Sponsor: Taiwan Liposome Company

Tien-Tzu Tai, MD, STUDY_DIRECTOR, Taiwan Liposome Company

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-30

Study Completion Date2026-08

Study Record Updates

Study Start Date2024-09-30

Study Completion Date2026-08

Terms related to this study

Additional Relevant MeSH Terms

Postsurgical Pain Management