RECRUITING

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial compares the effect of olaparib for one year versus two years, with or without bevacizumab, for the treatment of BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor and may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving olaparib for one year with or without bevacizumab may be effective in treating patients with BRCA 1/2 mutated or homologous recombination deficient stage III or IV ovarian cancer, when compared to two years of olaparib.

Official Title

A Phase III Trial of One vs. Two Years of Maintenance Olaparib, With or Without Bevacizumab, in Patients With BRCA1/2 Mutated or Homologous Recombination Deficient (HRD+) Ovarian Cancer Following Response to First Line Platinum-Based Chemotherapy

Quick Facts

Study Start:2025-03-12
Study Completion:2034-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06580314

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients with newly diagnosed, pathologically confirmed, Federation of Gynecology and Obstetrics (FIGO) stage III or IV ovarian cancer of the following types:
  2. * High grade serous
  3. * High grade endometrioid, and/or
  4. * Other epithelial ovarian cancer with BRCA1/2 deleterious alteration (germline or somatic)
  5. * Submission of pathology report is required
  6. * Ovarian cancer = ovarian, fallopian, or primary peritoneal cancer
  7. * Patients must have:
  8. * Documented variant (tumor or germline) in BRCA1 or BRCA2 that is predicted to be pathogenic or suspected pathogenic (deleterious alteration)
  9. * Submission of testing report is required. OR
  10. * BRCA 1/2 wildtype AND known HRD deficient tumor determined by any commercial or academic, Clinical Laboratory Improvement Act (CLIA)-certified laboratory (e.g., Myriad MyChoice©)
  11. * Submission of testing report is required
  12. * Patient must have undergone cytoreductive surgery (primary or interval)
  13. * Patients must have completed first line platinum-based therapy prior to registration:
  14. * Platinum based chemotherapy course must have consisted of a minimum of 4 treatment cycles and a maximum of 9, although it is strongly recommended that patients receive at least 6 cycles unless medically contraindicated
  15. * For those receiving less than 6 cycles of platinum-based therapy, the reason for this must be documented and could include hematologic toxicity or non-hematologic toxicities directly related to therapy
  16. * Intravenous, intraperitoneal, or neoadjuvant platinum-based chemotherapy is allowed; for weekly therapy, three weeks are considered one cycle
  17. * Patients must not have received an investigational agent during their first line course of chemotherapy
  18. * Patients must have, in the opinion of the investigator, no clinical evidence of disease progression following completion of this chemotherapy course (partial or complete response to platinum-based chemotherapy)
  19. * Patients with treated brain metastases are eligible if follow up brain imaging after central nervous system (CNS) directed therapy shows no evidence of progression following completion of this chemotherapy course (partial or complete response to platinum-based chemotherapy)
  20. * Patients must be randomized at least 3 weeks and no more than 12 weeks after their last dose of chemotherapy (last dose is the day of the last infusion of platinum agent)
  21. * No previous treatment with a PARP inhibitor, including olaparib, niraparib, and rucaparib
  22. * Age ≥ 18
  23. * Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2
  24. * Not pregnant and not nursing
  25. * Absolute neutrophil count (ANC) ≥ 1,500 cells/mm\^3
  26. * Platelets ≥ 100,000 cells/mm\^3
  27. * Hemoglobin ≥ 9 g/dl
  28. * Creatinine clearance (CrCL) of \> 30 mL/min by the Cockcroft-Gault formula
  29. * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (patients with known Gilbert's disease who have bilirubin level ≤ 3 x institutional ULN may be enrolled)
  30. * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional ULN
  31. * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
  32. * No active infection requiring parental antibiotic(s)
  33. * No current evidence of intra-abdominal abscess, abdominal/pelvic fistula (not diverted), gastrointestinal perforation, gastrointestinal (GI) obstruction, and/or need for drainage nasogastric or gastrostomy tube
  34. * No current inability to swallow orally administered medication
  35. * No history of myelodysplastic syndrome and/or acute myeloid leukemia
  36. * No history of allogeneic bone marrow transplant
  37. * No concomitant use of strong or moderate CYP3A inducers
  38. * No known hypersensitivity to olaparib or any of the excipients of the product
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Ying Liu
PRINCIPAL_INVESTIGATOR
NRG Oncology

Study Locations (Sites)

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
United States
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
United States
Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508
United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
United States
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
United States
Katmai Oncology Group
Anchorage, Alaska, 99508
United States
Providence Alaska Medical Center
Anchorage, Alaska, 99508
United States
Cancer Center at Saint Joseph's
Phoenix, Arizona, 85004
United States
Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903
United States
CARTI Cancer Center
Little Rock, Arkansas, 72205
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
United States
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, 93420
United States
Sutter Auburn Faith Hospital
Auburn, California, 95602
United States
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, 95603
United States
Kaiser Permanente-Bellflower
Bellflower, California, 90706
United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, 94704
United States
Tower Cancer Research Foundation
Beverly Hills, California, 90211
United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
United States
Mills-Peninsula Medical Center
Burlingame, California, 94010
United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, 95682
United States
Mercy Cancer Center - Carmichael
Carmichael, California, 95608
United States
Mercy San Juan Medical Center
Carmichael, California, 95608
United States
Eden Hospital Medical Center
Castro Valley, California, 94546
United States
Sutter Davis Hospital
Davis, California, 95616
United States
Kaiser Permanente Dublin
Dublin, California, 94568
United States
Mercy Cancer Center - Elk Grove
Elk Grove, California, 95758
United States
Kaiser Permanente-Fremont
Fremont, California, 94538
United States
Palo Alto Medical Foundation-Fremont
Fremont, California, 94538
United States
Fresno Cancer Center
Fresno, California, 93720
United States
Kaiser Permanente-Fresno
Fresno, California, 93720
United States
Kaiser Permanente South Bay
Harbor City, California, 90710
United States
Kaiser Permanente-Irvine
Irvine, California, 92618
United States
UC San Diego Moores Cancer Center
La Jolla, California, 92093
United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
United States
Kaiser Permanente West Los Angeles
Los Angeles, California, 90034
United States
Cedars Sinai Medical Center
Los Angeles, California, 90048
United States
Mercy Cancer Center
Merced, California, 95340
United States
Memorial Medical Center
Modesto, California, 95355
United States
Kaiser Permanente-Modesto
Modesto, California, 95356
United States
Palo Alto Medical Foundation-Camino Division
Mountain View, California, 94040
United States
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California, 94040
United States
Providence Queen of The Valley
Napa, California, 94558
United States
Sutter Cancer Research Consortium
Novato, California, 94945
United States
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
United States
Kaiser Permanente-Oakland
Oakland, California, 94611
United States
Palo Alto Medical Foundation Health Care
Palo Alto, California, 94301
United States
Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304
United States
Kaiser Permanente - Panorama City
Panorama City, California, 91402
United States
Huntington Memorial Hospital
Pasadena, California, 91105
United States
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670
United States
Kaiser Permanente- Marshall Medical Offices
Redwood City, California, 94063
United States
Kaiser Permanente-Richmond
Richmond, California, 94801
United States
Kaiser Permanente-Riverside
Riverside, California, 92505
United States
Mercy Cancer Center - Rocklin
Rocklin, California, 95765
United States
Rohnert Park Cancer Center
Rohnert Park, California, 94928
United States
Kaiser Permanente-Roseville
Roseville, California, 95661
United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, 95661
United States
Sutter Roseville Medical Center
Roseville, California, 95661
United States
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678
United States
Kaiser Permanente Downtown Commons
Sacramento, California, 95814
United States
Mercy Cancer Center - Sacramento
Sacramento, California, 95816
United States
Sutter Medical Center Sacramento
Sacramento, California, 95816
United States
Kaiser Permanente-South Sacramento
Sacramento, California, 95823
United States
South Sacramento Cancer Center
Sacramento, California, 95823
United States
Kaiser Permanente-San Diego Zion
San Diego, California, 92120
United States
California Pacific Medical Center-Pacific Campus
San Francisco, California, 94115
United States
Kaiser Permanente-San Francisco
San Francisco, California, 94115
United States
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
United States
Kaiser Permanente San Leandro
San Leandro, California, 94577
United States
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, 93401
United States
Kaiser Permanente-San Marcos
San Marcos, California, 92078
United States
Mills Health Center
San Mateo, California, 94401
United States
Kaiser San Rafael-Gallinas
San Rafael, California, 94903
United States
Ridley-Tree Cancer Center
Santa Barbara, California, 93105
United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
United States
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California, 95065
United States
Santa Cruz Radiation Oncology Medical Group
Santa Cruz, California, 95065
United States
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, 93444
United States
Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
United States
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, 95403
United States
Sutter Pacific Medical Foundation
Santa Rosa, California, 95403
United States
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, 95405
United States
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080
United States
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
United States
Saint Joseph's Medical Center
Stockton, California, 95204
United States
Kaiser Permanente-Stockton
Stockton, California, 95210
United States
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, 94086
United States
Torrance Memorial Physician Network - Cancer Care
Torrance, California, 90505
United States
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
United States
Kaiser Permanente-Vallejo
Vallejo, California, 94589
United States
Sutter Solano Medical Center/Cancer Center
Vallejo, California, 94589
United States
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
United States
John Muir Medical Center-Walnut Creek
Walnut Creek, California, 94598
United States
Kaiser Permanente-Woodland Hills
Woodland Hills, California, 91367
United States
Woodland Memorial Hospital
Woodland, California, 95695
United States
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045
United States
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
United States
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909
United States
Memorial Hospital North
Colorado Springs, Colorado, 80920
United States
Saint Francis Cancer Center
Colorado Springs, Colorado, 80923
United States
UCHealth - Cherry Creek
Denver, Colorado, 80206
United States
Mercy Medical Center
Durango, Colorado, 81301
United States
Southwest Oncology PC
Durango, Colorado, 81301
United States
Poudre Valley Hospital
Fort Collins, Colorado, 80524
United States
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado, 80528
United States
UCHealth Greeley Hospital
Greeley, Colorado, 80631
United States
UCHealth Highlands Ranch Hospital
Highlands Ranch, Colorado, 80129
United States
Saint Anthony Hospital
Lakewood, Colorado, 80228
United States
Longmont United Hospital
Longmont, Colorado, 80501
United States
Medical Center of the Rockies
Loveland, Colorado, 80538
United States
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
United States
Saint Anthony North Hospital
Westminster, Colorado, 80023
United States
Danbury Hospital
Danbury, Connecticut, 06810
United States
Norwalk Hospital
Norwalk, Connecticut, 06856
United States
Beebe Medical Center
Lewes, Delaware, 19958
United States
Beebe South Coastal Health Campus
Millville, Delaware, 19967
United States
Helen F Graham Cancer Center
Newark, Delaware, 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
United States
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
United States
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, 19801
United States
Holy Cross Hospital
Fort Lauderdale, Florida, 33308
United States
University of Florida Health Science Center - Gainesville
Gainesville, Florida, 32610
United States
Orlando Health Cancer Institute
Orlando, Florida, 32806
United States
Sacred Heart Hospital
Pensacola, Florida, 32504
United States
Northside Hospital
Atlanta, Georgia, 30342
United States
Augusta University Medical Center
Augusta, Georgia, 30912
United States
Hawaii Cancer Care - Westridge
'Aiea, Hawaii, 96701
United States
Pali Momi Medical Center
'Aiea, Hawaii, 96701
United States
Queen's Cancer Center - Pearlridge
'Aiea, Hawaii, 96701
United States
The Cancer Center of Hawaii-Pali Momi
'Aiea, Hawaii, 96701
United States
The Queen's Medical Center - West Oahu
'Ewa Beach, Hawaii, 96706
United States
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813
United States
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, 96813
United States
Queen's Medical Center
Honolulu, Hawaii, 96813
United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813
United States
University of Hawaii Cancer Center
Honolulu, Hawaii, 96813
United States
Kuakini Medical Center
Honolulu, Hawaii, 96817
United States
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
United States
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, 96817
United States
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819
United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
United States
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii, 96766
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
United States
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
United States
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
United States
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
United States
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83687
United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, 83864
United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
United States
OSF Saint Anthony's Health Center
Alton, Illinois, 62002
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
United States
Illinois CancerCare-Canton
Canton, Illinois, 61520
United States
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
United States
SIH Cancer Institute
Carterville, Illinois, 62918
United States
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
United States
Centralia Oncology Clinic
Centralia, Illinois, 62801
United States
Saint Mary's Hospital
Centralia, Illinois, 62801
United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612
United States
University of Illinois
Chicago, Illinois, 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
United States
Carle at The Riverfront
Danville, Illinois, 61832
United States
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
United States
Decatur Memorial Hospital
Decatur, Illinois, 62526
United States
Illinois CancerCare-Dixon
Dixon, Illinois, 61021
United States
Carle Physician Group-Effingham
Effingham, Illinois, 62401
United States
Crossroads Cancer Center
Effingham, Illinois, 62401
United States
Elmhurst Memorial Hospital
Elmhurst, Illinois, 60126
United States
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
United States
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
United States
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
United States
SSM Health Good Samaritan
Mount Vernon, Illinois, 62864
United States
Edward Hospital/Cancer Center
Naperville, Illinois, 60540
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451
United States
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
United States
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, 62269
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
United States
Illinois CancerCare-Peru
Peru, Illinois, 61354
United States
Valley Radiation Oncology
Peru, Illinois, 61354
United States
Edward Hospital/Cancer Center?Plainfield
Plainfield, Illinois, 60585
United States
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
United States
Springfield Clinic
Springfield, Illinois, 62702
United States
Springfield Memorial Hospital
Springfield, Illinois, 62781
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
Illinois CancerCare - Washington
Washington, Illinois, 61571
United States
IU Health North Hospital
Carmel, Indiana, 46032
United States
UChicago Medicine Northwest Indiana
Crown Point, Indiana, 46307
United States
Goshen Center for Cancer Care
Goshen, Indiana, 46526
United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
United States
Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana, 46202
United States
Ascension Saint Vincent Indianapolis Hospital
Indianapolis, Indiana, 46260
United States
Mary Greeley Medical Center
Ames, Iowa, 50010
United States
McFarland Clinic - Ames
Ames, Iowa, 50010
United States
McFarland Clinic - Boone
Boone, Iowa, 50036
United States
Mercy Hospital
Cedar Rapids, Iowa, 52403
United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
United States
Heartland Oncology and Hematology LLP
Council Bluffs, Iowa, 51503
United States
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa, 51503
United States
Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ
Council Bluffs, Iowa, 51503
United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, 50501
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
United States
McFarland Clinic - Jefferson
Jefferson, Iowa, 50129
United States
McFarland Clinic - Marshalltown
Marshalltown, Iowa, 50158
United States
Central Care Cancer Center - Garden City
Garden City, Kansas, 67846
United States
Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530
United States
Flaget Memorial Hospital
Bardstown, Kentucky, 40004
United States
Baptist Health Corbin
Corbin, Kentucky, 40701
United States
Commonwealth Cancer Center-Corbin
Corbin, Kentucky, 40701
United States
Baptist Health Lexington
Lexington, Kentucky, 40503
United States
Saint Joseph Hospital
Lexington, Kentucky, 40504
United States
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
United States
Saint Joseph Hospital East
Lexington, Kentucky, 40509
United States
Saint Joseph London
London, Kentucky, 40741
United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, 40202
United States
Baptist Health Louisville
Louisville, Kentucky, 40207
United States
UofL Health Medical Center Northeast
Louisville, Kentucky, 40245
United States
Saint Joseph Mount Sterling
Mount Sterling, Kentucky, 40353
United States
Baptist Health Paducah
Paducah, Kentucky, 42003
United States
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, 70805
United States
Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, 70808
United States
Our Lady of The Lake
Baton Rouge, Louisiana, 70808
United States
Our Lady of the Lake Medical Oncology
Baton Rouge, Louisiana, 70817
United States
University Medical Center New Orleans
New Orleans, Louisiana, 70112
United States
Ochsner Baptist Medical Center
New Orleans, Louisiana, 70115
United States
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine, 04074
United States
Walter Reed National Military Medical Center
Bethesda, Maryland, 20889-5600
United States
Christiana Care - Union Hospital
Elkton, Maryland, 21921
United States
MyMichigan Medical Center Gratiot
Alma, Michigan, 48801
United States
MyMichigan Medical Center Alpena
Alpena, Michigan, 49707
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109
United States
Bronson Battle Creek
Battle Creek, Michigan, 49017
United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114
United States
Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114
United States
University of Michigan - Brighton Center for Specialty Care
Brighton, Michigan, 48116
United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188
United States
Trinity Health Medical Center - Canton
Canton, Michigan, 48188
United States
Chelsea Hospital
Chelsea, Michigan, 48118
United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118
United States
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, 48346
United States
Newland Medical Associates-Clarkston
Clarkston, Michigan, 48346
United States
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
United States
Henry Ford River District Hospital
East China Township, Michigan, 48054
United States
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan, 49829
United States
Cancer Hematology Centers - Flint
Flint, Michigan, 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan, 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
United States
Hurley Medical Center
Flint, Michigan, 48503
United States
MyMichigan Medical Center Gladwin
Gladwin, Michigan, 48624
United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503
United States
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
United States
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan, 48236
United States
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan, 48236
United States
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods, Michigan, 48236
United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
United States
Ascension Borgess Cancer Center
Kalamazoo, Michigan, 49009
United States
Ascension Borgess Hospital
Kalamazoo, Michigan, 49048
United States
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
United States
Henry Ford Saint John Hospital - Macomb Medical
Macomb, Michigan, 48044
United States
Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan, 48044
United States
MyMichigan Medical Center Midland
Midland, Michigan, 48670
United States
MyMichigan Medical Center Mount Pleasant
Mount Pleasant, Michigan, 48858
United States
Trinity Health Muskegon Hospital
Muskegon, Michigan, 49444
United States
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan, 49120
United States
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan, 49444
United States
Hope Cancer Center
Pontiac, Michigan, 48341
United States
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan, 48341
United States
Newland Medical Associates-Pontiac
Pontiac, Michigan, 48341
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341
United States
Corewell Health Reed City Hospital
Reed City, Michigan, 49677
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085
United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, 49085
United States
MyMichigan Medical Center Tawas
Tawas City, Michigan, 48764
United States
Munson Medical Center
Traverse City, Michigan, 49684
United States
Henry Ford Health Warren Hospital
Warren, Michigan, 48093
United States
Henry Ford Madison Heights Hospital - Breast
Warren, Michigan, 48093
United States
Henry Ford Warren Hospital - GLCMS
Warren, Michigan, 48093
United States
University of Michigan Health - West
Wyoming, Michigan, 49519
United States
Huron Gastroenterology PC
Ypsilanti, Michigan, 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197
United States
Riverwood Healthcare Center
Aitkin, Minnesota, 56431
United States
Essentia Health - Baxter Clinic
Baxter, Minnesota, 56425
United States
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, 56401
United States
Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337
United States
Cambridge Medical Center
Cambridge, Minnesota, 55008
United States
Mercy Hospital
Coon Rapids, Minnesota, 55433
United States
Essentia Health - Deer River Clinic
Deer River, Minnesota, 56636
United States
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, 56501
United States
Essentia Health Cancer Center
Duluth, Minnesota, 55805
United States
Essentia Health Saint Mary's Medical Center
Duluth, Minnesota, 55805
United States
Miller-Dwan Hospital
Duluth, Minnesota, 55805
United States
Fairview Southdale Hospital
Edina, Minnesota, 55435
United States
Essentia Health - Ely Clinic
Ely, Minnesota, 55731
United States
Essentia Health - Fosston
Fosston, Minnesota, 56542
United States
Essentia Health Hibbing Clinic
Hibbing, Minnesota, 55746
United States
Essentia Health - International Falls Clinic
International Falls, Minnesota, 56649
United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
United States
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
United States
Health Partners Inc
Minneapolis, Minnesota, 55454
United States
Monticello Cancer Center
Monticello, Minnesota, 55362
United States
Essentia Health - Moose Lake Clinic
Moose Lake, Minnesota, 55767
United States
New Ulm Medical Center
New Ulm, Minnesota, 56073
United States
Essentia Health - Park Rapids
Park Rapids, Minnesota, 56470
United States
Fairview Northland Medical Center
Princeton, Minnesota, 55371
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
United States
Regions Hospital
Saint Paul, Minnesota, 55101
United States
United Hospital
Saint Paul, Minnesota, 55102
United States
Essentia Health Sandstone
Sandstone, Minnesota, 55072
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
United States
Lakeview Hospital
Stillwater, Minnesota, 55082
United States
Essentia Health Virginia Clinic
Virginia, Minnesota, 55792
United States
Ridgeview Medical Center
Waconia, Minnesota, 55387
United States
Rice Memorial Hospital
Willmar, Minnesota, 56201
United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
United States
Fairview Lakes Medical Center
Wyoming, Minnesota, 55092
United States
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri, 63011
United States
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613
United States
Cox Cancer Center Branson
Branson, Missouri, 65616
United States
Mercy Cancer Center - Cape Girardeau
Cape Girardeau, Missouri, 63703
United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
United States
Parkland Health Center - Farmington
Farmington, Missouri, 63640
United States
Freeman Health System
Joplin, Missouri, 64804
United States
Mercy Hospital Joplin
Joplin, Missouri, 64804
United States
Lake Regional Hospital
Osage Beach, Missouri, 65065
United States
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
United States
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri, 65401
United States
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
United States
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri, 63109
United States
Washington University School of Medicine
Saint Louis, Missouri, 63110
United States
Mercy Hospital South
Saint Louis, Missouri, 63128
United States
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
United States
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
United States
Mercy Hospital Springfield
Springfield, Missouri, 65804
United States
CoxHealth South Hospital
Springfield, Missouri, 65807
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
United States
Mercy Hospital Washington
Washington, Missouri, 63090
United States
Community Hospital of Anaconda
Anaconda, Montana, 59711
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
United States
Great Falls Clinic
Great Falls, Montana, 59405
United States
Hi-Line Sletten Cancer Center
Havre, Montana, 59501
United States
Logan Health Medical Center
Kalispell, Montana, 59901
United States
Saint Patrick Hospital - Community Hospital
Missoula, Montana, 59802
United States
Community Medical Center
Missoula, Montana, 59804
United States
CHI Health Saint Francis
Grand Island, Nebraska, 68803
United States
CHI Health Good Samaritan
Kearney, Nebraska, 68847
United States
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, Nebraska, 68114
United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114
United States
Oncology Associates PC
Omaha, Nebraska, 68114
United States
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
United States
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
United States
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
United States
Creighton University Medical Center
Omaha, Nebraska, 68131
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920
United States
Cooper Hospital University Medical Center
Camden, New Jersey, 08103
United States
Jersey City Medical Center
Jersey City, New Jersey, 07302
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645
United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
United States
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey, 08080
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
United States
Roswell Park Cancer Institute
Buffalo, New York, 14263
United States
Memorial Sloan Kettering Commack
Commack, New York, 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York, 10604
United States
NYU Langone Hospital - Long Island
Mineola, New York, 11501
United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
United States
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
United States
University of Rochester
Rochester, New York, 14642
United States
State University of New York Upstate Medical University
Syracuse, New York, 13210
United States
Memorial Sloan Kettering Nassau
Uniondale, New York, 11553
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599
United States
Duke University Medical Center
Durham, North Carolina, 27710
United States
Duke Women's Cancer Care Raleigh
Raleigh, North Carolina, 27607
United States
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota, 58103
United States
Essentia Health - Jamestown Clinic
Jamestown, North Dakota, 58401
United States
OhioHealth O'Bleness Hospital
Athens, Ohio, 45701
United States
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio, 44122
United States
Geauga Hospital
Chardon, Ohio, 44024
United States
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
United States
Bethesda North Hospital
Cincinnati, Ohio, 45242
United States
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, 45247
United States
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, 45255
United States
Case Western Reserve University
Cleveland, Ohio, 44106
United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, 44111
United States
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
United States
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214
United States
Riverside Methodist Hospital
Columbus, Ohio, 43214
United States
Grant Medical Center
Columbus, Ohio, 43215
United States
Doctors Hospital
Columbus, Ohio, 43228
United States
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
United States
Grady Memorial Hospital
Delaware, Ohio, 43015
United States
Columbus Oncology and Hematology Associates
Dublin, Ohio, 43016
United States
Dublin Methodist Hospital
Dublin, Ohio, 43016
United States
OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903
United States
OhioHealth Marion General Hospital
Marion, Ohio, 43302
United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124
United States
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio, 44060
United States
OhioHealth Pickerington Methodist Hospital
Pickerington, Ohio, 43147
United States
ProMedica Flower Hospital
Sylvania, Ohio, 43560
United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606
United States
OhioHealth Westerville Medical Campus/Westerville Cancer Center
Westerville, Ohio, 43082
United States
UH Seidman Cancer Center at Saint John Medical Center
Westlake, Ohio, 44145
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
United States
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, 97814
United States
Saint Charles Health System
Bend, Oregon, 97701
United States
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
United States
Bay Area Hospital
Coos Bay, Oregon, 97420
United States
Providence Newberg Medical Center
Newberg, Oregon, 97132
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, 97914
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon, 97045
United States
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, 97210
United States
Providence Portland Medical Center
Portland, Oregon, 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
United States
Oregon Health and Science University
Portland, Oregon, 97239
United States
Saint Charles Health System-Redmond
Redmond, Oregon, 97756
United States
Legacy Meridian Park Hospital
Tualatin, Oregon, 97062
United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
United States
Saint Luke's Cancer Center - Allentown
Allentown, Pennsylvania, 18104
United States
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania, 18015
United States
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017
United States
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
United States
Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301
United States
Saint Luke's Hospital-Anderson Campus
Easton, Pennsylvania, 18045
United States
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania, 18201
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
United States
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania, 19114
United States
Saint Luke's Hospital - Upper Bucks Campus
Quakertown, Pennsylvania, 18951
United States
Saint Luke's Hospital - Monroe Campus
Stroudsburg, Pennsylvania, 18360
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, 19090
United States
Women and Infants Hospital
Providence, Rhode Island, 02905
United States
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota, 57401
United States
Avera Cancer Institute at Pierre
Pierre, South Dakota, 57501
United States
Avera Cancer Institute at Yankton
Yankton, South Dakota, 57078
United States
Houston Methodist Hospital
Houston, Texas, 77030
United States
Memorial Hermann Texas Medical Center
Houston, Texas, 77030
United States
Methodist Willowbrook Hospital
Houston, Texas, 77070
United States
Houston Methodist West Hospital
Houston, Texas, 77094
United States
Houston Methodist Saint John Hospital
Nassau Bay, Texas, 77058
United States
Houston Methodist The Woodlands Hospital
The Woodlands, Texas, 77385
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
United States
University of Virginia Cancer Center
Charlottesville, Virginia, 22908
United States
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
United States
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
United States
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
United States
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington, 98026
United States
Providence Regional Cancer Partnership
Everett, Washington, 98201
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
United States
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
United States
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503
United States
PeaceHealth Saint John Medical Center
Longview, Washington, 98632
United States
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington, 98274
United States
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107
United States
Swedish Medical Center-Cherry Hill
Seattle, Washington, 98122-5711
United States
Swedish Medical Center-First Hill
Seattle, Washington, 98122
United States
PeaceHealth United General Medical Center
Sedro-Woolley, Washington, 98284
United States
Saint Michael Cancer Center
Silverdale, Washington, 98383
United States
Legacy Salmon Creek Hospital
Vancouver, Washington, 98686
United States
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362
United States
United Hospital Center
Bridgeport, West Virginia, 26330
United States
WVUH-Berkely Medical Center
Martinsburg, West Virginia, 25401
United States
West Virginia University Healthcare
Morgantown, West Virginia, 26506
United States
Camden Clark Medical Center
Parkersburg, West Virginia, 26101
United States
Princeton Community Hospital
Princeton, West Virginia, 24740
United States
Wheeling Hospital/Schiffler Cancer Center
Wheeling, West Virginia, 26003
United States
Duluth Clinic Ashland
Ashland, Wisconsin, 54806
United States
Northwest Wisconsin Cancer Center
Ashland, Wisconsin, 54806
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
United States
Essentia Health-Hayward Clinic
Hayward, Wisconsin, 54843
United States
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin, 54154
United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin, 53081
United States
Sheboygan Physicians Group
Sheboygan, Wisconsin, 53081
United States
Essentia Health-Spooner Clinic
Spooner, Wisconsin, 54801
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235-1495
United States
Essentia Health Saint Mary's Hospital - Superior
Superior, Wisconsin, 54880
United States
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
United States
Billings Clinic-Cody
Cody, Wyoming, 82414
United States

Collaborators and Investigators

Sponsor: NRG Oncology

  • Ying Liu, PRINCIPAL_INVESTIGATOR, NRG Oncology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-12
Study Completion Date2034-12-31

Study Record Updates

Study Start Date2025-03-12
Study Completion Date2034-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Fallopian Tube Endometrioid Adenocarcinoma
  • Fallopian Tube High Grade Serous Adenocarcinoma
  • FIGO Stage III Ovarian Cancer 2014
  • FIGO Stage IV Ovarian Cancer 2014
  • Ovarian Carcinoma
  • Ovarian High Grade Endometrioid Adenocarcinoma
  • Ovarian High Grade Serous Adenocarcinoma
  • Primary Peritoneal Endometrioid Adenocarcinoma
  • Primary Peritoneal High Grade Serous Adenocarcinoma