COMPLETED

Krill Oil for Pain in Elders

Conditions

Chronic Musculoskeletal Pain Chronic Pain

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Chronic musculoskeletal pain contributes to mobility disability among older adults. Nutritional interventions, like omega-3 fatty acids, may help manage pain and improve physical function. Supplementation with krill oil may offer advantages to fish oil due to better absorption and additional nutrients. This pilot study aims to assess the feasibility of a clinical trial to determine the impact of krill oil supplementation on pain and function in older adults, informing future research.

Official Title

Krill Oil for Pain and Physical Function in Older Adults

Quick Facts

Study Start:2025-01-17

Study Completion:2025-12-17

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT06580912

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Able to provide informed consent * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, aged ≥60 years * Exhibiting chronic musculoskeletal pain of the hip, knees, or lower back (\>3 months) * Average pain ≥4 on a 0-10 numeric rating scale * Exhibiting moderate mobility limitations (Short Physical Performance Battery score 4-10) * Ability to take oral supplements and be willing to adhere to the supplementation regimen * Agreement to adhere to Lifestyle Considerations throughout study duration	* Any known coagulation or bleeding disorders * Standing regimen of anticoagulants or full-dose aspirin * Regular use of opioids or high-dose NSAIDs * Taking medication known to affect muscle (e.g. steroids) * Taking selective serotonin reuptake inhibitors (SSRIs) * Omega-3 supplementation within the past 3 months * High consumption of fatty fish (\>2 servings/week) * Habitual supplementation with other complementary medicines/supplements that may affect the study results, including St. John's Wort * Known allergy to seafood * Clinically significant conditions: diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (\>150/90mmhg at baseline), cancer or cancer that has been in remission \>5 years * History of atrial fibrillation or atrial flutter * Dementia * History of smoking, alcohol abuse, or illicit drug use * Ambulatory impairments which would limit the ability to perform physical function tests * Treatment with another investigational drug or other intervention within 3 months * Planning a surgical procedure during the study period * Planning to permanently leave the area during the study period

Inclusion Criteria

Exclusion Criteria

* Able to provide informed consent
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Male or female, aged ≥60 years
* Exhibiting chronic musculoskeletal pain of the hip, knees, or lower back (\>3 months)
* Average pain ≥4 on a 0-10 numeric rating scale
* Exhibiting moderate mobility limitations (Short Physical Performance Battery score 4-10)
* Ability to take oral supplements and be willing to adhere to the supplementation regimen
* Agreement to adhere to Lifestyle Considerations throughout study duration

* Any known coagulation or bleeding disorders
* Standing regimen of anticoagulants or full-dose aspirin
* Regular use of opioids or high-dose NSAIDs
* Taking medication known to affect muscle (e.g. steroids)
* Taking selective serotonin reuptake inhibitors (SSRIs)
* Omega-3 supplementation within the past 3 months
* High consumption of fatty fish (\>2 servings/week)
* Habitual supplementation with other complementary medicines/supplements that may affect the study results, including St. John's Wort
* Known allergy to seafood
* Clinically significant conditions: diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (\>150/90mmhg at baseline), cancer or cancer that has been in remission \>5 years
* History of atrial fibrillation or atrial flutter
* Dementia
* History of smoking, alcohol abuse, or illicit drug use
* Ambulatory impairments which would limit the ability to perform physical function tests
* Treatment with another investigational drug or other intervention within 3 months
* Planning a surgical procedure during the study period
* Planning to permanently leave the area during the study period

Contacts and Locations

Principal Investigator

Javier A Tamargo, PhD

PRINCIPAL_INVESTIGATOR

University of Florida

Study Locations (Sites)

UF Claude D. Pepper Older Americans Independence Center

Gainesville, Florida, 32610

United States

Collaborators and Investigators

Sponsor: University of Florida

Javier A Tamargo, PhD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-17

Study Completion Date2025-12-17

Study Record Updates

Study Start Date2025-01-17

Study Completion Date2025-12-17

Terms related to this study

Keywords Provided by Researchers

Chronic Pain

Additional Relevant MeSH Terms

Chronic Musculoskeletal Pain