A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

Eligibility Criteria

• 1. Self-identifying Latinx, Spanish-speaking 2. Adults 18-64 years 3. Meet DSM-5 criteria for major depressive disorder as evaluated by study clinician 4. Montgomery-Asberg depression scale (MADRS) score of 20 or above at baseline 4. Participants must have an MGB psychiatrist and primary care provider.
• 1. History of primary psychotic disorder, by history
• 2. History Bipolar I disorder, by history
• 3. Unstable complex PTSD, as assessed by study clinician
• 4. History of dissociative identity disorder
• 5. History of neurocognitive disorder
• 6. History of severe and/or recent substance use disorder, by history and as assessed by study clinician after clinical evaluation and interview
• 7. Uncontrolled hypertension, tachycardia, or unstable cardiopulmonary disease, by history a. Blood pressure on initial screen must be \<140/90 mmHg.
• 8. History of aortic dissection
• 9. History of myocardial infarction
• 10. History of aneurysm
• 11. History of hepatic impairment.
• 12. History of epilepsy
• 13. History of prior hypersensitivity to ketamine
• 14. Body Mass Index greater than 35
• 15. Body Mass Index less than 18.5
• 16. Are pregnant, breastfeeding, or planning to become pregnant within 12 weeks of treatment completion
• 17. Enrolled in other clinical trial for the treatment of depression or other behavioral health diagnosis
• 18. Inability to provide consent.