RECRUITING

Effect of Cannabis on E-Cigarette Use Behavior

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes. The study's goals are to test demand for e-cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke e-cigarettes and either smoke or vape THC in the laboratory.

Official Title

Effect of Cannabinoids on Tobacco Product Demand and Pharmacodynamics: Electronic Cigarette Use

Quick Facts

Study Start:2025-03-19
Study Completion:2029-10-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06609109

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Healthy non-treatment seeking adults aged 21 or older
  2. 2. Report daily use of e-cigarettes
  3. 3. Biological confirmation of e-cigarette use: have an expired carbon monoxide (CO) level of less than 6 ppm and a positive urine cotinine test at screening
  4. 4. Report current use of cannabis (at least 1 occasion per week)
  5. 5. Have experience with the inhalation route of administration for cannabis
  6. 6. Biological confirmation of cannabis use: have a positive urinary THC drug test at screening.
  7. 7. For women of children bearing potential and men with female partners of child-bearing potential, must be willing to use an effective form of contraception during the study.
  1. 1. Report current intention to reduce or quit cannabis or tobacco use within the next 30 days
  2. 2. Meet Diagnostic and Statistical Manual (DSM-5) criteria for a substance use disorder other than alcohol, cannabis, or nicotine
  3. 3. Test positive for illicit drugs other than cannabis and tobacco
  4. 4. Positive breath alcohol test at study admission
  5. 5. Have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity
  6. 6. Have a lifetime history of suicidal behavior (i.e. past suicide attempt), or current suicidal behavior or ideation as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)
  7. 7. Are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding
  8. 8. Have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina)
  9. 9. Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.

Contacts and Locations

Study Contact

Lauren Morris, MHS
CONTACT
410-550-6953
lmorri20@jhmi.edu
Dustin Lee, PhD
CONTACT
410-550-4035
dlee214@jhmi.edu

Principal Investigator

Dustin Lee, PhD
PRINCIPAL_INVESTIGATOR
Johns Hopkins School of Medicine

Study Locations (Sites)

Johns Hopkins University Behavioral Pharmacology Research Unit
Baltimore, Maryland, 21224
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Dustin Lee, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-19
Study Completion Date2029-10-01

Study Record Updates

Study Start Date2025-03-19
Study Completion Date2029-10-01

Terms related to this study

Keywords Provided by Researchers

  • cannabis
  • e-cigarette
  • electronic cigarette
  • marijuana
  • THC
  • Tobacco

Additional Relevant MeSH Terms

  • Cannabis Use
  • Tobacco Use
  • Electronic Cigarette Use