RECRUITING

High-flow Nasal Oxygen Therapy for Advanced Endoscopy in High-risk Patients.

Description

Anesthesia is crucial during upper GI endoscopy in order to improve the procedural conditions for the interventionist, increase the quality of examination and alleviate patient discomfort. However, sedation during endoscopy carries a serious risk of blood oxygen desaturation. This study aims to investigate the hypothesis if the application of high-flow nasal oxygen (HFNO) during high-risk gastroscopy reduces the risk of blood oxygen levels to drop below a defined threshold. Enrolled patients will be randomly assigned to either the control group, receiving standard care during endoscopy, or the intervention group, receiving HFNO therapy during the procedure. Throughout the intervention, vital parameters will be recorded. Care providers will be asked to answer a questionnaire that specifically evaluates the effect of HFNO on patient safety and the procedure.

Study Overview

Study Details

Study overview

Anesthesia is crucial during upper GI endoscopy in order to improve the procedural conditions for the interventionist, increase the quality of examination and alleviate patient discomfort. However, sedation during endoscopy carries a serious risk of blood oxygen desaturation. This study aims to investigate the hypothesis if the application of high-flow nasal oxygen (HFNO) during high-risk gastroscopy reduces the risk of blood oxygen levels to drop below a defined threshold. Enrolled patients will be randomly assigned to either the control group, receiving standard care during endoscopy, or the intervention group, receiving HFNO therapy during the procedure. Throughout the intervention, vital parameters will be recorded. Care providers will be asked to answer a questionnaire that specifically evaluates the effect of HFNO on patient safety and the procedure.

High-flow Nasal Oxygen Versus Face Mask or Nasal Cannula for Advanced Endoscopy in High-risk Patients

High-flow Nasal Oxygen Therapy for Advanced Endoscopy in High-risk Patients.

Condition
Hypoxemia During Surgery
Intervention / Treatment

-

Contacts and Locations

Boston

Anesthesia, Critical Care and Pain Medicine Department at Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Upper endoscopy (EGD, ERCP, EUC etc.) w/wo colonoscopy expected duration \> 15 min under MAC
  • * one or more of the following:
  • * Diagnosis of sleep apnea
  • * BMI ≥ 30 kg/m2
  • * Baseline SpO2 \< 96% or Requirement for long-term oxygen therapy
  • * BOSTN score ≥ 2
  • * BMI ≥ 30 kg/m2
  • * Observed apnea
  • * Observed loud Snoring
  • * Daytime Tiredness
  • * Neck circumference ≥ 16.5 inches in female, ≥ 17.5 inches in male
  • * Known Pregnancy
  • * Known Current infection with COVID-19
  • * Planned general anesthesia

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Beth Israel Deaconess Medical Center,

Study Record Dates

2025-07