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Circadian Mechanisms, Glucose, and CV Risks in T1D

Description

People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance the understanding of mechanisms by which improving sleep regularity influences glycemic control and cardiovascular risk in T1D.

Conditions

Type 1 Diabetes (T1D)
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Related Conditions:

Type 1 Diabetes (T1D)

Study Overview

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Study Details

Study overview

People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance the understanding of mechanisms by which improving sleep regularity influences glycemic control and cardiovascular risk in T1D.

Circadian Mechanisms of Glycemic Control and Cardiovascular Risk in Adults With Type 1 Diabetes

Circadian Mechanisms, Glucose, and CV Risks in T1D

Condition
Type 1 Diabetes (T1D)
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Illinois Chicago, Chicago, Illinois, United States, 60612

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults 18-50 years with a clinical diagnosis of T1D for at least one year
  • * Report habitual sleep irregularity ≥1 hour/week
  • * Desire to improve sleep, and own a smartphone (Android or iPhone)
  • * Self-reported A1C within the past 6 months ≥10%
  • * insomnia symptoms defined as Insomnia Severity Index score ≥15
  • * history of restless leg syndrome
  • * history of severe hypoglycemia (defined as hypoglycemic episode that results in loss of consciousness, seizure, or requiring emergency room visit or hospitalization) within the past 6 months
  • * rotating shift or night work or routinely sleeping after 3 AM.
  • * use of sleep medications/aids, significant medical comorbidities (such as heart failure, cirrhosis, chronic obstructive pulmonary disease requiring oxygen, active treatment for cancer, on renal replacement therapy \[dialysis\])
  • * depression (Patient Health Questionnaire 8 \[PHQ-8\] score ≥15)
  • * history of stroke with neurological deficits
  • * pregnant, breast feeding, or planning pregnancy, as sleep and glucose are known to change during pregnancy and breastfeeding.
  • * Allergy to lidocaine Participants who passed the first screen by phone will be scheduled for a consenting visit at UIC

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Illinois at Chicago,

Study Record Dates

2029-08