Preliminary Characterization of Commercial Kratom Extract Products

Eligibility Criteria

• * 1) \>21 years old;
• * 2) Experienced kratom extract product consumer of one of the leading US brands listed in the study protocol;
• * 3) Reports a specific kratom extract product brand and specific dose amount (or range of typical dose amount) on the online screener;
• * 4) English language proficient;
• * 5) Willingness to provide requested samples of the kratom extract product currently being taken.
• * 1) Reports any acute adverse or unexpected or otherwise sudden health event related to their typical kratom product dose that occurred within 30 days of screening;
• * 2) Having ever sought medical attention for an acute adverse health event as a result of taking any kratom product;
• * 3) Cannot or will not provide their kratom extract product samples in the form of an unopened package that is clearly labeled with at least the product and vendor name;
• * 4)The kratom extract product used by the participant has any semi-synthetic or fully synthetic ingredient listed or is known by the study team to have such an ingredient;
• * 5) Currently breastfeeding or pregnant;
• * 6) history or current diagnosis of psychotic disorder;
• * 7) current untreated bipolar disorder; 8) current untreated major depressive disorder;
• * 8) Current physical dependence on alcohol, benzodiazepines, or opioids (self-reported or otherwise evidenced) requiring medical intervention;
• * 9) Reports use of fentanyl within the past month and/or has a fentanyl positive drug screen;
• * 10) Discordance between self-reported substance use and drug screen results obtained during screening;
• * 11)Any physical, psychiatric, environmental, situational, or kratom product-related condition considered by the study team to increase risk or undue burden.