RECRUITING

Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure and decreased blood flow causes vascular hypoperfusion of the spinal cord and exacerbates the severity of injury. This is also referred to as secondary injury. Thus, knowledge of spinal cord hypoperfusion would allow the treating physician to optimize the hemodynamic condition of the patient with acute spinal cord injury and potentially improve functional outcomes.

Official Title

Contrast-Enhanced Ultrasound Biomarker for Prognostication and Guidance of Surgical Treatment in Acute Traumatic Spinal Cord Injury

Quick Facts

Study Start:2023-09-28
Study Completion:2027-12-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06654804

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18 years of age minimum
  2. * Acute spinal cord injury fpr less than 24 hours
  3. * Injury ranging from mild spinal cord injury where motor function is preserved (AIS A) to complete injury where there is no motor or sensory function below the leel of the injury (AIS D)
  4. * Medically stable to undergo routine dorsal decompression, spinal realignment
  5. * and stabilizing with segmental instrumentation
  1. * Younger than 18 years old
  2. * Neurological lower extremity exam missing or intact
  3. * Traumatic head injury with a Glasgow score of 11 or lower
  4. * Cord injury level caudal to T10 (thoracic spine level 10)
  5. * A known sensitivity to lipid microsphere or its components, such as polyethylene glycol (PEG)
  6. * A history of anaphylactoid reactions from ultrasound enhancing agents
  7. * A known history of cardiopulmonary conditions
  8. * Cardiac shunt

Contacts and Locations

Study Contact

Amy Anderson
CONTACT
206-744-9364
amya9@uw.edu

Principal Investigator

Christoph Hofstetter, MD, PhD
PRINCIPAL_INVESTIGATOR
University of Washington

Study Locations (Sites)

University of Washington Harborview Medical Center
Seattle, Washington, 98104
United States

Collaborators and Investigators

Sponsor: University of Washington

  • Christoph Hofstetter, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Washington

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-09-28
Study Completion Date2027-12-15

Study Record Updates

Study Start Date2023-09-28
Study Completion Date2027-12-15

Terms related to this study

Additional Relevant MeSH Terms

  • Acute Spinal Cord Injury