RECRUITING

A Phase II Open-label Study of Olutasidenib Post-transplant Maintenance Therapy for Patients With IDH1-mutated Myeloid Malignancies

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical research study is to learn about the safety and tolerability of giving olutasidenib to patients with IDH1-mutated myeloid malignancies as maintenance therapy after they receive a stem cell transplant.

Official Title

A Phase II Open-label Study of Olutasidenib Post-transplant Maintenance Therapy for Patients With IDH1-mutated Myeloid Malignancies

Quick Facts

Study Start:2024-12-31

Study Completion:2029-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06668584

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Diagnosis of AML, MDS, MPN, CMML according to World Health Organization (WHO) classification that underwent first or second alloSCT with either peripheral blood or bone marrow hematopoietic stem cell source, regardless of donor type/match, conditioning regimen, or GVHD prophylaxis and is at least 30 days post stem cell transplant until day 120. 2. Evdence of an IDH1 mutation presence by next generation sequencing panel at original diagnosis. 3. Evidence of engraftment by Absolute neutrophil count (ANC) \>/= 1.0x 109/L without daily use of myeloid growth factor (G-CSF) for at least 7 days; and Platelet \>/= 30 x 109/L with out platelet transfusion within 1 week. 4. Patient in morphologic remission with Day +30 bone marrow \<5% blast. Will include MRD positive or negative. 5. Age 18 to 75 years old. 6. ECOG performance status of 0, 1, 2. Or KPS above 70. 7. Creatinine clearance greater or equal to 40cc/min as defined by the Cockcroft-Gault Equation. 8. Serum bilirubin \</= 1.5 x upper limit of normal (ULN) except in subjects with Gilbert's Syndrome in whom total bilirubin must be \</= 3.0 mg/dl. Aspartate transaminase (AST) or alanine transaminase (ALT) \</= 2.5 x ULN. Alkaline phoshatase \</=2.5 x ULN. 9. No active bleeding. 10. No clinical evidence of life-threatening infection. 11. Capable of understanding the investigational nature, potential risks, and benefits of the study, and able to provide valid informed consent. 12. Negative serum or urine pregancy test for wome with reproductive potential at screening. 13. Female participants of non-childbearing potential must meet at least one of the following criteria: 1. Postmenopausal (no menses in greater than or equal to 12 consecutive months). 2. History of hysterectomy or bilateral salpingo-oophorectomey. 3. Ovarian failure (follicle-stimulating hormone and Estradiolin menopausal range, who have received Whole Pelvic Radiation Therapy). 4. History of bilateral tubal ligation or another surgical sterilization procedure 14. Subjects who are of childbearing potential, sexually active, and at risk of pregnancy must agree to use a highly effective method of contraception for the duration of the active treatment and at least 3 months post-completion of the study therapy. See Appendix B.	1. Use of any of the following after transplantation and prior to starting study therapy. Anti-leukemic agents given as post-transplant maintenance therapy (e.g., subcutaneous, or oral 5-azacitidine or FL T3 inhibitors for maintenance) 2. Overall grade II-IV aGVHD. However, upon complete resolution of aGVHD-related symptoms with grade 1 or 0 overall clinical grade would be appropriate to enroll at that time. Patients may be eligible for enrollment if they are on prednisone 0.5 mg/kg daily dose or lower, tacrolimus, sirolimus, and/or ruxolitinib. 3. cGVHD, moderate or servere by NIH criteria. 4. Active uncontrolled systemic fungal, bacterial, or viral infection. However, patients receiving anti-micobial agents including antibiotics, antiviral and antifungal therapies are allowed if the infection is controlled, and the patient is hemodynamically stable. 5. Known active viral infection with Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV). * Patients with known active hepatitis B virus (HBV) infection will be excluded because of potential effects on immune function and/or drug interactions. However, if a patient has HBV history with an undetectable HBV load by polymerase chain reaction (PCR), no liver-related complications, and is on definitive HBV therapy that is not contraindicated in this study, then they would be eligible for study. * Patients with known active hepatitis C virus (HCV) infection will be excluded because of potential effects on immune function and/or drug interactions. However, if a patient with a history of HCV infection has received definitive therapy (and is now HCV viral load negative), or if a patient has a reactive HCV antibody test but has an undetectable viral load by PCR, then they would be eligible. * Patients with known active HIV infection will be excluded out of concern for the drug-drug interaction with venetoclax and highly active antiretroviral therapy (HART) 6. QT prolongation of QTc \>480 milliseconds. 7. Any other condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures. 8. Patients with cognitive impairments or psychiatric disorders that can interfere with safety or with obtaining informed consent of compliance with study procedures.

Inclusion Criteria

Exclusion Criteria

1. Diagnosis of AML, MDS, MPN, CMML according to World Health Organization (WHO) classification that underwent first or second alloSCT with either peripheral blood or bone marrow hematopoietic stem cell source, regardless of donor type/match, conditioning regimen, or GVHD prophylaxis and is at least 30 days post stem cell transplant until day 120.
2. Evdence of an IDH1 mutation presence by next generation sequencing panel at original diagnosis.
3. Evidence of engraftment by Absolute neutrophil count (ANC) \>/= 1.0x 109/L without daily use of myeloid growth factor (G-CSF) for at least 7 days; and Platelet \>/= 30 x 109/L with out platelet transfusion within 1 week.
4. Patient in morphologic remission with Day +30 bone marrow \<5% blast. Will include MRD positive or negative.
5. Age 18 to 75 years old.
6. ECOG performance status of 0, 1, 2. Or KPS above 70.
7. Creatinine clearance greater or equal to 40cc/min as defined by the Cockcroft-Gault Equation.
8. Serum bilirubin \</= 1.5 x upper limit of normal (ULN) except in subjects with Gilbert's Syndrome in whom total bilirubin must be \</= 3.0 mg/dl. Aspartate transaminase (AST) or alanine transaminase (ALT) \</= 2.5 x ULN. Alkaline phoshatase \</=2.5 x ULN.
9. No active bleeding.
10. No clinical evidence of life-threatening infection.
11. Capable of understanding the investigational nature, potential risks, and benefits of the study, and able to provide valid informed consent.
12. Negative serum or urine pregancy test for wome with reproductive potential at screening.
13. Female participants of non-childbearing potential must meet at least one of the following criteria:
1. Postmenopausal (no menses in greater than or equal to 12 consecutive months).
2. History of hysterectomy or bilateral salpingo-oophorectomey.
3. Ovarian failure (follicle-stimulating hormone and Estradiolin menopausal range, who have received Whole Pelvic Radiation Therapy).
4. History of bilateral tubal ligation or another surgical sterilization procedure
14. Subjects who are of childbearing potential, sexually active, and at risk of pregnancy must agree to use a highly effective method of contraception for the duration of the active treatment and at least 3 months post-completion of the study therapy. See Appendix B.

1. Use of any of the following after transplantation and prior to starting study therapy. Anti-leukemic agents given as post-transplant maintenance therapy (e.g., subcutaneous, or oral 5-azacitidine or FL T3 inhibitors for maintenance)
2. Overall grade II-IV aGVHD. However, upon complete resolution of aGVHD-related symptoms with grade 1 or 0 overall clinical grade would be appropriate to enroll at that time. Patients may be eligible for enrollment if they are on prednisone 0.5 mg/kg daily dose or lower, tacrolimus, sirolimus, and/or ruxolitinib.
3. cGVHD, moderate or servere by NIH criteria.
4. Active uncontrolled systemic fungal, bacterial, or viral infection. However, patients receiving anti-micobial agents including antibiotics, antiviral and antifungal therapies are allowed if the infection is controlled, and the patient is hemodynamically stable.
5. Known active viral infection with Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV).
* Patients with known active hepatitis B virus (HBV) infection will be excluded because of potential effects on immune function and/or drug interactions. However, if a patient has HBV history with an undetectable HBV load by polymerase chain reaction (PCR), no liver-related complications, and is on definitive HBV therapy that is not contraindicated in this study, then they would be eligible for study.
* Patients with known active hepatitis C virus (HCV) infection will be excluded because of potential effects on immune function and/or drug interactions. However, if a patient with a history of HCV infection has received definitive therapy (and is now HCV viral load negative), or if a patient has a reactive HCV antibody test but has an undetectable viral load by PCR, then they would be eligible.
* Patients with known active HIV infection will be excluded out of concern for the drug-drug interaction with venetoclax and highly active antiretroviral therapy (HART)
6. QT prolongation of QTc \>480 milliseconds.
7. Any other condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures.
8. Patients with cognitive impairments or psychiatric disorders that can interfere with safety or with obtaining informed consent of compliance with study procedures.

Contacts and Locations

Study Contact

Jeremy Ramdial, MD

CONTACT

(713) 745-0146

jlramdial@mdanderson.org

Principal Investigator

Jeremy Ramdial, MD

PRINCIPAL_INVESTIGATOR

M.D. Anderson Cancer Center

Study Locations (Sites)

The University of Texas M. D. Anderson Cancer Center

Houston, Texas, 77030

United States

Collaborators and Investigators

Sponsor: M.D. Anderson Cancer Center

Jeremy Ramdial, MD, PRINCIPAL_INVESTIGATOR, M.D. Anderson Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12-31

Study Completion Date2029-12-31

Study Record Updates

Study Start Date2024-12-31

Study Completion Date2029-12-31

Terms related to this study

Additional Relevant MeSH Terms

Myeloid Malignancies