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Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3

Description

This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of two different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.

Study Overview

Study Details

Study overview

This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of two different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3 (COBRA)

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3

Condition
Cannabis
Intervention / Treatment

-

Contacts and Locations

Boulder

Center for Innovation and Creativity (CINC), Boulder, Colorado, United States, 80301

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Must be between the ages of 21 and 40 and provide informed consent;
  • 2. Must be right-handed (Laterality Quotient \> 60 on Edinburgh Handedness Inventory - Short Form);
  • 3. Must use cannabis at least 4 days during the month;
  • 4. Must be a cannabis user for at least a year;
  • 5. Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days, during the Pre-Screening;
  • 6. Must not test positive on a urine toxicology test for drugs of abuse at the Baseline appointment;
  • 7. Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days;
  • 8. Must not be a regular nicotine user (≤4 days per week; cigarette, E-cigs, or smokeless);
  • 9. Must not have used caffeine or nicotine (cigarette, E-cigs, or smokeless) for 4 hours before each appointment;
  • 10. Must have a breath alcohol level of 0 at Baseline appointment (to sign consent form);
  • 11. Must not be actively seeking or in treatment for any substance use disorder;
  • 12. Female subjects must not be or trying to become pregnant (as indicated by a pregnancy test administered at Baseline appointment);
  • 13. Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders;
  • 14. Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-quality EEG recording.

Ages Eligible for Study

21 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

L. Cinnamon Bidwell,

Timothy Curran, PhD, PRINCIPAL_INVESTIGATOR, University of Colorado, Boulder

Study Record Dates

2026-01