RECRUITING

A Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a multi-center, open-label study to investigate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary activity of REC-1245 administered orally on a once daily (QD) schedule in participants with unresectable, locally advanced, or metastatic solid tumors.

Official Title

A Phase 1 / 2, Open-Label Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer

Quick Facts

Study Start:2024-11-21
Study Completion:2028-10-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06678659

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18 years or older
  2. * Have histologically-confirmed unresectable, locally advanced, or metastatic select solid tumors or select relapsed / refractory lymphoma
  3. * Have experienced progressive disease, relapsed disease, or be intolerant to at least one established standard systemic anti-cancer treatment for a given tumor type, or have been considered ineligible for standard therapy.
  4. * Eastern cooperative oncology group (ECOG) performance status ≤ 1
  5. * Measurable disease at baseline per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 / Lugano criteria and documented by computed tomography (CT) and / or magnetic resonance imaging (MRI)
  1. * Received treatment with another RBM39 degrader
  2. * Clinically significant gastrointestinal (GI) or GI malabsorption

Contacts and Locations

Study Locations (Sites)

City of Hope
Duarte, California, 91010
United States
Cleveland Clinic
Cleveland, Ohio, 44195
United States
SCRI Oncology Partners - PPDS
Nashville, Tennessee, 37203
United States
START Mountain Region
West Valley City, Utah, 84119
United States

Collaborators and Investigators

Sponsor: Recursion Pharmaceuticals Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-11-21
Study Completion Date2028-10-30

Study Record Updates

Study Start Date2024-11-21
Study Completion Date2028-10-30

Terms related to this study

Keywords Provided by Researchers

  • RBM39
  • Cancer
  • Refractory Lymphomas
  • Metastatic Cancers

Additional Relevant MeSH Terms

  • Unresectable
  • Locally Advanced
  • Metastatic Cancers
  • Relapsed/Refractory Lymphomas