RECRUITING

Early Amiodarone in Shockable Cardiac Arrest

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.

Official Title

Early Amiodarone in Shockable Cardiac Arrest (Early-Amio) Study

Quick Facts

Study Start:2025-01-01
Study Completion:2028-01-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06680869

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest
  2. * Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia
  3. * Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt
  1. * Known allergy to amiodarone
  2. * EMS-assessed contraindication to amiodarone
  3. * Pre-existing "do-not-attempt-resuscitation" orders
  4. * Inter-facility transportations
  5. * Initial care by a non-participating EMS agency able to perform advanced life support interventions
  6. * Pediatric patient as determined by EMS
  7. * Prisoners
  8. * Pregnant patients

Contacts and Locations

Study Contact

Joshua Lupton, MD, MPH
CONTACT
(503) 418-6706
lupton@ohsu.edu

Principal Investigator

Joshua Lupton, MD, MPH
PRINCIPAL_INVESTIGATOR
Oregon Health and Science University

Study Locations (Sites)

Oregon Health & Sciences University
Portland, Oregon, 97035
United States

Collaborators and Investigators

Sponsor: Oregon Health and Science University

  • Joshua Lupton, MD, MPH, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-01
Study Completion Date2028-01-31

Study Record Updates

Study Start Date2025-01-01
Study Completion Date2028-01-31

Terms related to this study

Additional Relevant MeSH Terms

  • Cardiac Arrest