RECRUITING

How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.

Official Title

The Acute Effects of an Endurance Exercise Bout the Gut Microbiome and Gut-derived Metabolome in Women's Distinct Fitness and Body Mass Indexes

Quick Facts

Study Start:2024-10-16
Study Completion:2025-10-16
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06691100

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 40 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Biological sex: female
  2. * BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2
  3. * Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)
  4. * Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).
  1. * Biological sex: male
  2. * BMI \< 19 kg/m2 or \> 40 kg/m2
  3. * Currently pregnant, \< 2 years postpartum, lactating
  4. * Currently taking any herbal, fiber, or prebiotic supplement
  5. * Current or 1-month before the study, taking oral or vaginal antibiotics
  6. * Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.

Contacts and Locations

Study Contact

Carmen Ortega-Santos, PhD, RD
CONTACT
2029942757
carmen.ortegasantos@gwu.edu

Study Locations (Sites)

Milken Institute School of Public Health, The George Washington University
Washington, District of Columbia, 20037
United States

Collaborators and Investigators

Sponsor: George Washington University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-16
Study Completion Date2025-10-16

Study Record Updates

Study Start Date2024-10-16
Study Completion Date2025-10-16

Terms related to this study

Keywords Provided by Researchers

  • Gut Microbiota
  • Womens Health
  • Exercise
  • Weight Management
  • Obesity

Additional Relevant MeSH Terms

  • Weight Management
  • Obesity
  • Exercise
  • Women
  • Gut Microbiome
  • Metabolome
  • Health
  • Gut Microbiota