RECRUITING

Early Versus Late Adjunctive Vasopressin in Septic Shock

Description

The goal of the CASPER-Pilot study is to develop clinical decision support (CDS) technology within Epic to randomize patients with septic shock to early versus standard of care vasopressin initiation. The primary aim of this study will be to test the hypothesis that CDS technology can be utilized to create two distinct cohorts of patients reflecting different times of vasopressin initiation based on norepinephrine dose requirements. Secondarily, this study will evaluate the proportion of patients whose norepinephrine dose at the time of vasopressin initiation is within the specified range for the intervention arm they were randomized to. Other outcomes of evaluation will include adherence to the developed CDS technology and comparison of clinical outcomes between the two treatment arms.

Conditions

SepsisSeptic Shock
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Related Conditions:

SepsisSeptic Shock

Study Overview

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Study Details

Study overview

The goal of the CASPER-Pilot study is to develop clinical decision support (CDS) technology within Epic to randomize patients with septic shock to early versus standard of care vasopressin initiation. The primary aim of this study will be to test the hypothesis that CDS technology can be utilized to create two distinct cohorts of patients reflecting different times of vasopressin initiation based on norepinephrine dose requirements. Secondarily, this study will evaluate the proportion of patients whose norepinephrine dose at the time of vasopressin initiation is within the specified range for the intervention arm they were randomized to. Other outcomes of evaluation will include adherence to the developed CDS technology and comparison of clinical outcomes between the two treatment arms.

Clinical Decision Support Assistance to Randomize Patients to Early or Late Adjunctive Vasopressin in Septic Shock

Early Versus Late Adjunctive Vasopressin in Septic Shock

Condition
Sepsis
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 18 Years
  • * Diagnosis of Septic Shock
  • * Admitted to Cleveland Clinic Main Campus Medical ICU
  • * Receiving continuous infusion of norepinephrine at a dose \> 5 mcg/min at time of enrollment
  • * Administration of any other vasoactive agent other than norepinephrine at time of enrollment
  • * Initiation of vasopressin by provider outside of the context of study when NE \< 10 mcg/min (before BPA firing)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The Cleveland Clinic,

Gretchen L. Sacha, PharmD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2025-12-31