A Study to Evaluate BMS-986278 in Participants With Normal Renal Function, Severe Renal Impairment, or End-Stage Renal Disease on Intermittent Hemodialysis

Eligibility Criteria

• * Body mass index (BMI) between 18 and 45 kg/m2 inclusive, and body weight ≥ 50 kg at screening. Note: for ESRD participants, this body weight should be the prescription dry weight.
• * Severe Renal Impaired Participants:
• 1. Participant has a supine SBP ≥ 90 and ≤ 180 mmHg, supine DBP ≥ 60 and ≤ 100 mmHg, and heart rate ≥ 40 and ≤ 110 beats per minute.
• 2. Participant has severe RI as defined by an eGFR ˂ 30 mL/min and not requiring dialysis at screening.
• 3. Participant must be medically stable for at least 1 month before study intervention administration.
• * Participants with ESRD:
• 1. Participant has ESRD as defined by an eGFR \< 15 mL/min at screening.
• 2. Participant required to be on intermittent hemodialysis, an average of 3 hemodialysis treatments per week prior to screening.
• 3. Participant has demonstrated adequate hemodialysis measurements (at least 2 Kt/V measurements ≥ 1.2 or 2 urea reduction ratio measurements ≥ 65%) within the 3 months prior to screening.
• * Healthy participant should have a supine SBP ≥ 90 and ≤ 160 mm Hg, supine DBP ≥ 50 and ≤ 100 mm Hg, and heart rate ≥ 40 and ≤ 100 beats per minute.
• * Healthy participants should have normal renal function, as defined by having an eGFR ≥ 90 mL/min eGFR at screening (calculated using the CKD-EPI equation).
• * Participant with any significant medical condition, laboratory abnormality, or psychiatric illness.
• * Any surgical or medical condition(s) possibly affecting drug absorption, distribution, metabolism, or excretion (eg, bariatric procedure or cholecystectomy).
• * Individuals who are of childbearing potential, breastfeeding, or currently pregnant.
• * Other protocol defined inclusion/exclusion criteria apply.