RECRUITING

A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase II trial is being done to develop and test a healthy eating program to reduce cancer recurrence (cancer that has come back after a period of improvement) and/or progression (cancer that is growing, spreading, or getting worse) in patients with non-muscle invasive bladder cancer (NMIBC). Researchers want to better understand how incorporating more cruciferous vegetables in the diet may reduce the risk of cancer recurrence or progression in men and women who were diagnosed with early-stage bladder cancer and compare whether extending the program can further improve bladder cancer outcomes. POW-R Health is a behavioral dietary intervention designed to modestly increase cruciferous vegetable (cruciferae) intake in patients. Cruciferous vegetables, such as cabbage, kale and broccoli, arugula, contain phytochemicals known as isothiocyanates (ITCs). Dietary ITCs exert potent anticancer activities against bladder cancer and can be rapidly metabolized, delivered to the bladder, and concentrated in the urine. Participating in the healthy eating program may reduce bladder cancer recurrence or progression in NMIBC survivors.

Official Title

A Scalable Cruciferous Vegetable Intervention to Reduce Bladder Cancer Recurrence and Progression

Quick Facts

Study Start:2026-01-13
Study Completion:2029-02-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06733363

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * English speaking
  2. * Diagnosed with stage Tis, Ta, or T1 bladder cancer
  3. * Age 18 years old or older (no upper limit)
  4. * Resides in New York State
  5. * Cancer not reported by a lab, nursing home, or death certificate/autopsy only
  6. * Did not receive a partial or radical cystectomy
  7. * Does not have other cancer diagnosis within 12 month of bladder cancer diagnosis nor under active treatment for any other cancers
  1. * Participants who had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier
  2. * Adults unable to consent
  3. * Adults unable to complete study measures in English
  4. * Individuals who are not yet adults (infants, children, teenagers)
  5. * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  6. * Unwilling or unable to follow protocol requirements
  7. * The following special populations ae excluded from this study:
  8. * Cognitively impaired adults/adults with impaired decision-making capacity
  9. * Individuals who are not yet adults (infants, children, teenagers)
  10. * Pregnant women
  11. * Prisoners

Contacts and Locations

Study Contact

Karen Yeary, MD
CONTACT
8772757724
askroswell@roswellpark.org

Principal Investigator

Karen Yeary, MD
PRINCIPAL_INVESTIGATOR
Roswell Park Comprehensive Cancer Center

Study Locations (Sites)

Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263
United States

Collaborators and Investigators

Sponsor: Roswell Park Cancer Institute

  • Karen Yeary, MD, PRINCIPAL_INVESTIGATOR, Roswell Park Comprehensive Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2026-01-13
Study Completion Date2029-02-28

Study Record Updates

Study Start Date2026-01-13
Study Completion Date2029-02-28

Terms related to this study

Additional Relevant MeSH Terms

  • Non-Muscle Invasive Bladder Carcinoma
  • Recurrent Bladder Carcinoma
  • Recurrent Non-Muscle Invasive Bladder Carcinoma
  • Stage 0a Bladder Cancer AJCC v8
  • Stage 1 Bladder Cancer AJCC v8