This phase III trial compares the effect of adding radiation therapy to usual care on the occurrence of bone-related complications in cancer patients with high-risk bone metastases that are not causing symptoms (asymptomatic). High-risk bone metastases are defined by their location (including hip, shoulder, long bones, and certain levels of the spine), or size (2 cm or larger). These bone metastases appear to be at higher risk of complications such as fracture, spinal cord compression, and/or pain warranting surgery or radiation treatment. Radiation therapy uses high energy x-rays to kill cancer cells and shrink tumors. The total dose of radiation can be delivered in a single day or divided in smaller doses for up to 5 days of total treatment. Usual care for asymptomatic bone metastases may include drugs that prevent bone loss, in addition to the treatment for the primary cancer or observation (which means no treatment until symptoms appear). Evidence has shown that preventative radiation therapy may be effective in lowering the number of bone metastases-related complications, however, it is not known if this approach is superior to usual care. Adding radiation therapy to usual care may be more effective in preventing bone-related complications than usual care alone in cancer patients with asymptomatic high-risk bone metastases.
This phase III trial compares the effect of adding radiation therapy to usual care on the occurrence of bone-related complications in cancer patients with high-risk bone metastases that are not causing symptoms (asymptomatic). High-risk bone metastases are defined by their location (including hip, shoulder, long bones, and certain levels of the spine), or size (2 cm or larger). These bone metastases appear to be at higher risk of complications such as fracture, spinal cord compression, and/or pain warranting surgery or radiation treatment. Radiation therapy uses high energy x-rays to kill cancer cells and shrink tumors. The total dose of radiation can be delivered in a single day or divided in smaller doses for up to 5 days of total treatment. Usual care for asymptomatic bone metastases may include drugs that prevent bone loss, in addition to the treatment for the primary cancer or observation (which means no treatment until symptoms appear). Evidence has shown that preventative radiation therapy may be effective in lowering the number of bone metastases-related complications, however, it is not known if this approach is superior to usual care. Adding radiation therapy to usual care may be more effective in preventing bone-related complications than usual care alone in cancer patients with asymptomatic high-risk bone metastases.
Comparing Radiation Therapy to Usual Care for Patients With High-Risk Bone Asymptomatic Metastases
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Fairbanks Memorial Hospital, Fairbanks, Alaska, United States, 99701
Cancer Center at Saint Joseph's, Phoenix, Arizona, United States, 85004
Kaiser Permanente-Deer Valley Medical Center, Antioch, California, United States, 94531
Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande, California, United States, 93420
Sutter Auburn Faith Hospital, Auburn, California, United States, 95602
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, United States, 95603
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield, California, United States, 93301
Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, United States, 94704
Mills-Peninsula Medical Center, Burlingame, California, United States, 94010
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, United States, 95682
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
ALL
No
NRG Oncology,
2028-10-01