Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * All individuals 18 years and older within the Institution's inpatient Psychiatry Unit with a Montgomery-Asberg Depression Rating Scale score ≥ 20
- * Must have a diagnosis of moderate to severe Major Depressive Disorder
- * Structured Clinical Interview for DSM-5 (SCID-5) will be performed to confirm MDD diagnosis
- * Adult patients with an allergy to ketamine
- * Adult patients with an allergy to Midazolam
- * Individuals with a history of mania/hypomania or diagnosis of of bipolar disorder
- * Patients on lithium and/or lamotrigine therapy
- * Recent or current homicidal ideation with an intent to act
- * MDD with psychotic features or current or past diagnosis of a psychotic disorder
- * No substance use disorder in the preceding 3 months except nicotine or caffeine or a positive urine screen for substances (except cannabis)
- * Diagnosis of obsessive-compulsive disorder, antisocial personality disorder, borderline personality disorder, posttraumatic stress disorder, intellectual disability, altered mental status, pregnant or breastfeeding patients,
- * Patients on \> 2 medications for hypertension
- * Patients with uncontrolled hypertension (BP \>140 mm Hg systolic and/or \>90 mm Hg diastolic on two separate readings at the time of screening)
- * Body weight of \> 150kg
- * Patients with history of congestive cardiac failure
- * Day of presentation, patients with unstable vital signs (systolic blood pressure \<90 or\>160 mm Hg, pulse rate \<50 or \>150 beats/min, and respiration rate \<10 or \>30 breaths/min)
- * Consumption of opioids within 24 hours of drug administration
- * Acutely intoxicated patients will also be excluded
Ages Eligible for Study
18 Years to 88 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No