RECRUITING

Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia

Description

This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia. The lung and oral cancers that plague Appalachia are fueled by cigarette smoking. Oral nicotine pouches which contain nicotine but no tobacco leaf, present a new opportunity to reduce cancer risk among Appalachian adults who smoke. Oral nicotine pouches and nicotine replacement therapy may work well to reduce cigarette use for smokers in rural Appalachia.

Conditions

Cigarette Smoking-Related Carcinoma
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Related Conditions:

Cigarette Smoking-Related Carcinoma

Study Overview

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Study Details

Study overview

This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia. The lung and oral cancers that plague Appalachia are fueled by cigarette smoking. Oral nicotine pouches which contain nicotine but no tobacco leaf, present a new opportunity to reduce cancer risk among Appalachian adults who smoke. Oral nicotine pouches and nicotine replacement therapy may work well to reduce cigarette use for smokers in rural Appalachia.

Testing Oral Nicotine Pouches to Reduce Smoking-Related Cancer in Rural Appalachia

Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia

Condition
Cigarette Smoking-Related Carcinoma
Intervention / Treatment

-

Contacts and Locations

Columbus

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States, 43210

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Read and speak English
  • * 21 years or older
  • * Smoke ≥ 5 cigarettes per day for the past year
  • * Willing to use Oral Nicotine Pouches (ONP) or Nicotine Replacement Therapy (NRT)
  • * Live in a rural Appalachian County
  • * Have a smartphone and/or willing to use a smartphone for study purposes (smartphones may be provided to participants for study purposes only)
  • * Willing to blow air into a handheld study device
  • * If capable of becoming pregnant, verbal confirmation of not being pregnant based on urine pregnancy test results
  • * Report currently using smoking cessation medications, NRT, or actively seeking treatment for smoking cessation
  • * Use of ONPs in past 3 months
  • * Use of Nicotine Replacement Therapies in past 3 months
  • * Use of other tobacco products \> 10 days/month
  • * Unstable or significant medical condition
  • * Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
  • * History of cardiac event or distress within the past 3 months
  • * Live in same household as another study participant.
  • * Currently pregnant, planning to become pregnant within 6 months, or breastfeeding

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ohio State University Comprehensive Cancer Center,

Brittney L Keller-Hamilton, PhD, MPH, PRINCIPAL_INVESTIGATOR, Ohio State University Comprehensive Cancer Center

Study Record Dates

2028-12-31