RECRUITING

Combining Spinal Cord Transcutaneous Stimulation and Activity-based Training in Inpatient Rehabilitation to Facilitate Upper Limb Function of Individuals with Acute to Subacute Cervical Spinal Cord Injury

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this clinical trial is to understand the safety and practicality of using spinal cord transcutaneous (through the skin) stimulation in an inpatient setting as well as how the combination of activity-based training (ABT) and spinal cord transcutaneous stimulation (scTS) can improve participants' ability to use their hands, arms, and trunk in an inpatient rehabilitation program. The main questions it aims to answer are: * Is the combination of spinal cord transcutaneous stimulation and ABT is safe and practical when applied to individuals with acute to subacute cervical SCI during inpatient rehabilitation? * How the combined intervention can improve hand and arm function when applied to those individuals? The investigators will assess the safety, feasibility, and preliminary efficacy of the combined intervention and compare to a sham control (sham stimulation combined with ABT) and a ABT only group to see if the combined intervention can lead to greater function recovery. Participants will: * Receive one type of the three intervention (scTS+ABT, sham scTS+ABT, or ABT only) for 10 sessions with 30 mins/session over 2 weeks. * Receive assessment before, during, and immediately after the intervention, and at 1-month, 2-month, and 3-month follow-up visits.

Official Title

Establishing the Feasibility, Safety, and Efficacy of Spinal Cord Transcutaneous Stimulation with Activity-based Training for Upper Extremity Function Recovery in Individuals with Acute to Subacute Tetraplegia

Quick Facts

Study Start:2024-04-08
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06773286

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * must be at least 18 years of age.
  2. * must have had a spinal cord injury for less than or equal to 8 weeks.
  3. * must have a traumatic cervical SCI with lesions (AIS A or B, C5-C7).
  4. * must have some degree of motor dysfunction in the hand (bilateral UE motor score \<25).
  5. * must be medically stable enough to participate in activity-based recovery training.
  6. * must be able to tolerate spinal cord transcutaneous stimulation, as determined by study staff.
  7. * must have ability to understand and the willingness to sign an informed consent.
  1. * have a history of seizures, head trauma and/or cognitive deficit
  2. * have surgically implanted foreign bodies such as a pacemaker, metal plate in the skull, and metal inside the skull
  3. * have a pressure sore or skin issues.
  4. * have severe spasticity.
  5. * in medically unstable condition.
  6. * have a history of illicit drug abuse.
  7. * have a history of medical disorders of my heart, lungs, bladder, kidneys or other parts of my body that are unrelated to my spinal cord injury.
  8. * unable or unwilling to wean from anti-spasticity medication (for an example: baclofen, Xeomin, and Lioresal).
  9. * unable to meet the attendance requirements.
  10. * currently enrolled in another interventional research study.
  11. * unable to follow instructions and maintain alertness during assessments and training.

Contacts and Locations

Study Contact

Fan Zhang, PhD
CONTACT
4015362070
fzhang@kesslerfoundation.org
Gail Forrest, PhD
CONTACT
973-324-3518
GForrest@kesslerfoundation.org

Principal Investigator

Gail Forrest, PhD
STUDY_DIRECTOR
Kessler Foundation

Study Locations (Sites)

Kessler Foundation
West Orange, New Jersey, 07052
United States

Collaborators and Investigators

Sponsor: Kessler Foundation

  • Gail Forrest, PhD, STUDY_DIRECTOR, Kessler Foundation

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-08
Study Completion Date2025-12

Study Record Updates

Study Start Date2024-04-08
Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

  • Spinal Cord Injury
  • Inpatient Rehabilitation
  • Upper Extremity
  • Spinal Cord Transcutaneous Stimulation
  • Activity-based Training

Additional Relevant MeSH Terms

  • Spinal Cord Injury Cervical