RECRUITING

Mindfulness for Cognition in Early-stage Alzheimer's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and structure? 3. How does mindfulness affect daily function and quality of life? Researchers will compare all outcomes to one other groups. In one group, individuals will participate in a mindfulness class intervention; in the other group, individuals will not engage in any active interventions immediately, but will be placed on a waitlist for the mindfulness intervention. Researchers will compare all outcomes between the groups groups to determine whether the mindfulness interventions leads to greater improvement compared to no intervention (waitlist group). Participants will: * Be randomly assigned to participate in the mindfulness intervention, or no immediate intervention (waitlist) * Complete paper-and-pencil cognitive testing, surveys, computerized tasks, and neuroimaging measures (EEG and MRI) before and after the intervention Outcomes will be assess at baseline, 2 months, 4 months and 6 months.

Official Title

Mechanisms of Mindfulness for Cognition in Early-Stage Alzheimer's Disease

Quick Facts

Study Start:2025-01-23
Study Completion:2027-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06792877

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Healthy older adults will show cognitive performance within 1.0 SD for age \& education adjusted norms on a neuropsychological test battery
  2. * Mild cognitive impairment (MCI) participants will show performance on delayed recall or one more or more other cognitive domains worse than 1.5 SD for age \& education adjusted norms, an MMSE score between 25-30, and a MoCA score between 20-30.
  1. * Participants without a computer, smart phone and internet access will be excluded
  2. * If they cannot understand the informed consent form or have moderate dementia.
  3. * Mood disorders (e.g., PTSD, depression, anxiety) or alcohol and drug use that either interferes with day-to-day life or required hospitalization within the past 5 years
  4. * Cerebrovascular disease
  5. * Any medical condition whose severity could significantly impair cognition (e.g., stroke, frontotermporal dementia, Parkinson's disease) are exclusionary

Contacts and Locations

Study Contact

Katherine W Turk, MD
CONTACT
8573645429
ctcnbrainlab@gmail.com
Kathy Y Xie, PhD
CONTACT
8572300905
ctcnbrainlab@gmail.com

Study Locations (Sites)

VA Boston Healthcare System - Jamaica Plain Campus
Boston, Massachusetts, 02130
United States

Collaborators and Investigators

Sponsor: VA Boston Healthcare System

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-23
Study Completion Date2027-03-31

Study Record Updates

Study Start Date2025-01-23
Study Completion Date2027-03-31

Terms related to this study

Keywords Provided by Researchers

  • Mindfulness
  • Aging
  • Mild Cognitive Impairment (MCI)
  • Cognition
  • Memory
  • Alzheimers Disease
  • Social Group

Additional Relevant MeSH Terms

  • Mild Cognitive Impairment (MCI)
  • Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
  • TBI (Traumatic Brain Injury)
  • Aging
  • Healthy Elderly
  • Alzheimer's Dementia (AD)