RECRUITING

IPV and Lung Compliance in Invasively Ventilated Children

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation. The main questions it aims to answer are: 1. Does IPV improve lung compliance 15 minutes after and 3 hours after receiving one treatment in a heterogeneous group of pediatric patients? 2. Does IPV improve lung compliance in patients with Pediatric Acute Respiratory Distress Syndrome (PARDS), and what is the degree of change compared to those without PARDS? 3. What is the effect of IPV on lung compliance according to PARDS severity (mild-moderate disease vs. severe disease). 4. What is the incidence of adverse effects of IPV? Participants will receive IPV because their medical team feels it will help their lung recovery and has already determined them to be safe candidates to receive this therapy, which is a standard airway clearance modality already routinely used in our PICU. Nothing additional will happen to participants as a result of this study. Enrolling in this study simply gives the study team permission to collect specific health information that identifies your child for research purposes, which may include results from medical tests found in their medical record and information from your child's bedside monitor and ventilator. This information will be collected before and after the IPV treatments to evaluate their response to the therapy.

Official Title

The Effect of Intrapulmonary Percussive Ventilation (IPV) on Lung Compliance in Critically Ill Pediatric Patients Requiring Invasive Mechanical Ventilation.

Quick Facts

Study Start:2025-01-13
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06836050

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:0 Days to 18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * ≤18 years old on conventional intermittent mandatory ventilation in the PICU that the physician deems is a candidate for IPV
  1. * The inability to accurately obtain ventilator measurements

Contacts and Locations

Study Contact

Alexandra B Cummings, DO
CONTACT
631-223-6032
acummingsdel@northwell.edu
Todd Sweberg, MD
CONTACT
718-470-3668
tsweberg@northwell.edu

Principal Investigator

Todd Sweberg, MD
PRINCIPAL_INVESTIGATOR
Northwell Health

Study Locations (Sites)

Cohen Children's Medical Center
New Hyde Park, New York, 11040
United States

Collaborators and Investigators

Sponsor: Northwell Health

  • Todd Sweberg, MD, PRINCIPAL_INVESTIGATOR, Northwell Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-13
Study Completion Date2026-12

Study Record Updates

Study Start Date2025-01-13
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • Lung Compliance
  • Pediatric
  • Pediatric Acute Respiratory Distress Syndrome (PARDS)
  • Intrapulmonary Percussive Ventilation (IPV)

Additional Relevant MeSH Terms

  • Pediatric Acute Respiratory Distress Syndrome (PARDS)
  • Pediatric Respiratory Diseases
  • Lung Compliance