A Phase 2 in Adult Subjects With Hereditary Angioedema

Eligibility Criteria

• * Must have given written informed consent and be able to comply with all study requirements.
• * Males or females 18 to 70 years of age at the time of informed consent.
• * Documented diagnosis of HAE-1/HAE-2.
• * At least 2 HAE attacks within the 8-week run-in period, as confirmed by an investigator based on the protocol-specified definition
• * Access to and ability to use ≥ 1 acute medication(s)
• * Female subjects must be non-pregnant;non-lactating, and either surgically sterile
• * Male subjects with WOCBP partners, dual contraception is required if no surgically sterile
• * Any clinically significant medical or psychiatric condition or medical history that, in the opinion of the Investigator, makes the subject unsuitable for participation in the study
• * Any concomitant diagnosis of another form of chronic angioedema, such as acquired angioedema, HAE with normal C1-INH, idiopathic angioedema, or recurrent angioedema associated with urticaria
• * History or presence of carcinoma within 5 years prior to screening, except for basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix that has been successfully treated.
• * Have undergone major surgery within 3 months prior to screening.
• * History of clinically significant arterial or venous thrombosis, or current clinically significant prothrombotic or bleeding risk
• * History of allergic reaction to an oligonucleotide or N-acetylgalactosamine
• * Prior treatment with any oligonucleotides within 6 months if single dose or 12 months if multiple doses prior to screening.
• * Exposure to another investigational drug or biological agent within 30 days or within at least 5 half-lives prior to screening.
• * With ANY of the abnormalities in clinical laboratory tests at screening and run-in period
• * Clinically significant findings on 12-lead electrocardiogram that would place the patient at risk or interfere with participation in the study at screening.
• * Positive for Human immunodeficiency virus (HIV), HBsAg, Hepatitis C or syphilis infection
• * Active infection requiring systemic antiviral or antimicrobial therapy that will not be completed prior to dosing.