RECRUITING

Phase 2b Study of EVO756 in Adults With Moderate to Severe Chronic Spontaneous Urticaria (CSU)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will evaluate the efficacy and safety of different doses of EVO756 in adults with moderate to severe chronic spontaneous urticaria (CSU).

Official Title

A Randomized, Double-Blind, Placebo Controlled, Dose-Ranging Study Evaluating the Efficacy and Safety of EVO756 in Adults With Moderate to Severe Chronic Spontaneous Urticaria

Quick Facts

Study Start:2025-03-20
Study Completion:2026-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06873516

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Confirmed CSU diagnosis for at least 3 months with an inadequate response to H1-antihistamines.
  2. * Subjects who are taking H1-antihistamines must be on a stable regimen 4 weeks prior to Day 1 and while on study.
  3. * Urticaria Activity Score (UAS7) equal to or greater than 16 at Day 1. UAS entries must be completed for a minimum of 4 out of the 7 days prior to Day 1.
  1. * Any clinically significant abnormality in laboratory evaluations, physical examinations, vital signs, or ECG at Screening, according to the Investigator's discretion.
  2. * Use of certain medications.
  3. * History of diseases with urticaria or angioedema symptoms, other than CSU and symptomatic dermographism.
  4. * Significant medical history other than CSU, or any other condition which might interfere with the evaluation of CSU.

Contacts and Locations

Study Contact

Polina Bukshpun
CONTACT
+1-818-536-2358
polina.bukshpun@evommune.com

Study Locations (Sites)

Cahaba Dermatology Skin Health Center
Birmingham, Alabama, 35244
United States
Velocity Clinical Research, Mobile
Mobile, Alabama, 36608
United States
Center for Dermatology Clinical Research
Fremont, California, 94538
United States
Antelope Valley Clinical Trials
Lancaster, California, 93534
United States
Northridge Clinical Trials
Northridge, California, 91325
United States
Integrated Research of Inland
Upland, California, 91786
United States
FOMAT Medical Research
Ventura, California, 93003
United States
AMR Fort Myers
Fort Myers, Florida, 33912
United States
The Indiana Clinical Trials Center
Plainfield, Indiana, 46168
United States
Bluegrass Allergy Care
Lexington, Kentucky, 40509
United States
Delricht Research Louisville
Louisville, Kentucky, 40205
United States
Delricht Research Louisiana
Baton Rouge, Louisiana, 70809
United States
Velocity Clinical Research, Lafayette
Lafayette, Louisiana, 70508
United States
Delricht Research
New Orleans, Louisiana, 70115
United States
Boston Specialists
Boston, Massachusetts, 02111
United States
Delricht Research - Priority Care
Charlotte, North Carolina, 28205
United States
Toledo Institute of Clinical Research
Toledo, Ohio, 43617
United States
AMR Myrtle Beach
Myrtle Beach, South Carolina, 29572
United States
National Allergy and Asthma Research
North Charleston, South Carolina, 29420
United States
Delricht Research Smyrna
Smyrna, Tennessee, 37167
United States
Studies in Dermatology
Cypress, Texas, 77429
United States
Western Sky Medical Research
El Paso, Texas, 79912
United States
Delricht Research - Lockhard Matter Dermatology
Prosper, Texas, 75078
United States
AMR Utah
Layton, Utah, 84041
United States
Seattle Clinical Research Center
Seattle, Washington, 98104
United States
Allergy, Asthma, and Sinus Center
Greenfield, Wisconsin, 53228
United States

Collaborators and Investigators

Sponsor: Evommune, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-20
Study Completion Date2026-05

Study Record Updates

Study Start Date2025-03-20
Study Completion Date2026-05

Terms related to this study

Keywords Provided by Researchers

  • chronic spontaneous urticaria
  • CSU
  • chronic hives
  • hives
  • idiopathic urticaria
  • urticaria

Additional Relevant MeSH Terms

  • Chronic Spontaneous Urticaria