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Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Description

Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.

Conditions

Hypercholesterolemia and Hyperlipidemia
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Related Conditions:

Hypercholesterolemia and Hyperlipidemia

Study Overview

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Study Details

Study overview

Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.

Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Condition
Hypercholesterolemia and Hyperlipidemia
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Washington University School of Medicine, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. age ≥ 18 and \< 40 years
  • 2. BMI ≥ 18.5 and \< 25.0 kg/m2
  • 3. baseline serum LDL-c \< 150 mg/dL (\< 3.9 mmol/L)
  • 4. baseline serum TG \< 100 mg/dL (\< 1.1 mmol/L)
  • 5. HbA1c ≤ 5.6%.
  • 1. personal or family history of familial hypercholesterolemia
  • 2. current use of lipid-lowering drugs
  • 3. currently on a ketogenic diet and unwilling to change diet
  • 4. current tobacco use
  • 5. hypertension
  • 6. prediabetes or diabetes
  • 7. elevated Lp(a) \> 6.5% of ApoB-containing lipoproteins at baseline
  • 8. oral contraceptive use
  • 9. contraindication to heparin
  • 10. known atherosclerotic cardiovascular disease
  • 11. unwilling to abstain from alcohol

Ages Eligible for Study

18 Years to 39 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Washington University School of Medicine,

Max C Petersen, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

2030-11-30