RECRUITING

Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

Description

This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.

Conditions

ANOCA - Angina With Non-obstructive Coronary ArteriesINOCA (Ischemia With Non Obstructive Coronary Artery Disease)
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Related Conditions:

ANOCA - Angina With Non-obstructive Coronary ArteriesINOCA (Ischemia With Non Obstructive Coronary Artery Disease)

Study Overview

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Study Details

Study overview

This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.

Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

Condition
ANOCA - Angina With Non-obstructive Coronary Arteries
Intervention / Treatment

-

Contacts and Locations

Plano

Baylor Scott & White The Heart Hospital - Plano, Plano, Texas, United States, 75093

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Aged 18 or older
  • 2. Patient being evaluated for ANOCA or INOCA
  • 3. Clinical suspicion for angina
  • 4. Patient should be able to comply with the protocol.
  • 5. Provide written informed consent before study participation.
  • 1. Existing coronary artery disease
  • 2. Previous percutaneous interventions within the coronaries
  • 3. Current use (within 48 hours) of long-acting nitrate therapies
  • 4. Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil)
  • 5. Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study.
  • 6. Children below 18 years, prisoners, pregnant people and patients who are unable to provide consent are excluded.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Baylor Research Institute,

Study Record Dates

2026-06-01