RECRUITING

Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

Conditions

ANOCA - Angina With Non-obstructive Coronary Arteries INOCA (Ischemia With Non Obstructive Coronary Artery Disease)Coronary Reactivity Testing Intracoronary Nitroglycerine

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.

Official Title

Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

Quick Facts

Study Start:2025-05-21

Study Completion:2026-06-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06896903

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Aged 18 or older 2. Patient being evaluated for ANOCA or INOCA 3. Clinical suspicion for angina 4. Patient should be able to comply with the protocol. 5. Provide written informed consent before study participation.	1. Existing coronary artery disease 2. Previous percutaneous interventions within the coronaries 3. Current use (within 48 hours) of long-acting nitrate therapies 4. Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil) 5. Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study. 6. Children below 18 years, prisoners, pregnant people and patients who are unable to provide consent are excluded.

Inclusion Criteria

Exclusion Criteria

1. Aged 18 or older
2. Patient being evaluated for ANOCA or INOCA
3. Clinical suspicion for angina
4. Patient should be able to comply with the protocol.
5. Provide written informed consent before study participation.

1. Existing coronary artery disease
2. Previous percutaneous interventions within the coronaries
3. Current use (within 48 hours) of long-acting nitrate therapies
4. Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil)
5. Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study.
6. Children below 18 years, prisoners, pregnant people and patients who are unable to provide consent are excluded.

Contacts and Locations

Study Contact

Bonnie Ostergren

CONTACT

469-814-4181

Bonnie.Ostergren@bswhealth.org

Study Locations (Sites)

Baylor Scott & White The Heart Hospital - Plano

Plano, Texas, 75093

United States

Collaborators and Investigators

Sponsor: Baylor Research Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-21

Study Completion Date2026-06-01

Study Record Updates

Study Start Date2025-05-21

Study Completion Date2026-06-01

Terms related to this study

Keywords Provided by Researchers

Coronary Reactivity Testing
Intracoronary Nitroglycerine

Additional Relevant MeSH Terms

ANOCA - Angina With Non-obstructive Coronary Arteries
INOCA (Ischemia With Non Obstructive Coronary Artery Disease)