RECRUITING

Lebrikizumab in Moderate-to-severe Atopic Dermatitis

Conditions

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research is studying a drug already approved for the treatment of atopic dermatitis (AD). This research collects health-related information and blood and skin samples to understand if the study drug, lebrikizumab, leads to long-term improvement in AD skin.

Official Title

Mechanism of Action for Lebrikizumab in Moderate-to-severe Atopic Dermatitis

Quick Facts

Study Start:2025-07

Study Completion:2027-06

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06906497

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Established diagnosis of AD for at least 1 year before the screening visit and topical treatment was inadequate or inadvisable. * Moderate-to-severe AD with involvement \> 10% of body-surface-area (BSA) and investigator global assessment (IGA) score =3 (based on the IGA scale ranging from 0 to 4, in which 3 is moderate and 4 is severe) at both the screening and baseline visits. * Subject has an Eczema Area and Severity Index (EASI) score =16 at screening and baseline. * Subject has a pruritus NRS =4. * Subject is biologic naïve. * Female subjects of childbearing potential (i.e., fertile, following menarche and until becoming post-menopausal unless permanently sterile) must agree either to commit to true abstinence throughout the study and for at least 17 weeks after the last study drug (SD) injection, when this is in line with the preferred and usual lifestyle of the subject, or to use a highly-effective and approved method of contraception throughout the study and for at least 17 weeks after the last study drug injection. * Subject willing and able to comply with all of the clinical study protocol's time commitments and procedural requirements. * Understand and sign an informed consent form (ICF) (and assent form, when applicable) before any investigational procedure(s) are performed.	* Previous treatment with lebrikizumab or participation in a lebrikizumab study. * History of anaphylaxis as defined by the Sampson criteria. * Treatment with topical corticosteroids, calcineurin inhibitors, Jak inhibitors, or crisaborole within 1 week prior to the baseline visit. * Prior treatment with dupilumab or tralokinumab. * Treatment with any of the following agents within 4 weeks prior to the baseline visit: 1. Immunosuppressive/immunomodulating drugs (e.g., systemic corticosteroids, cyclosporine, mycophenolate-mofetil, IFN-., Janus kinase inhibitors (JAKi), azathioprine, methotrexate). 2. Phototherapy and photochemotherapy (PUVA) for AD. * Treatment with the following prior to the baseline visit: 1. An investigational drug within 8 weeks or 5 half-lives (if known), whichever is longer. 2. Cell-depleting biologics, including to rituximab, within 6 months. 3. Other biologics within 5 half-lives (if known) or 16 weeks, whichever is longer. * Use of prescription moisturizers within 7 days of the baseline visit. * Regular use (more than 2 visits per week) of a tanning booth/parlor within 4 weeks of the screening visit. * Treatment with a live (attenuated) vaccine within 12 weeks of the baseline visit or planned during the study. * Uncontrolled chronic disease that might require bursts of oral corticosteroids, e.g., co-morbid severe uncontrolled asthma requiring systemic \[oral and/or parenteral\] corticosteroid treatment or hospitalization for \> 24 hours). * Active chronic or acute infection requiring treatment with systemic antibiotics, antivirals, anti-parasitics, antiprotozoals, or antifungals within 2 weeks before the baseline visit, or superficial skin infections within 1 week before the baseline visit. NOTE: patients may be rescreened after infection resolves. * Evidence of active acute or chronic hepatitis (as defined by the Department of Health \& Human Services Centers for Disease Control and Prevention) or known liver cirrhosis. * Diagnosed active endoparasitic infections or at high risk of these infections. * Known or suspected history of immunosuppression, including history of invasive opportunistic infections (e.g., tuberculosis \[TB\], histoplasmosis, listeriosis, coccidioidomycosis, pneumocystosis, and aspergillosis) despite infection resolution: or unusually frequent, recurrent, or prolonged infections, per the Investigator's judgment. * History of human immunodeficiency virus (HIV) infection or positive HIV serology at screening. * In the Investigator's opinion, any clinically significant laboratory results from the chemistry, hematology or urinalysis tests available in the medical history. * Presence of skin comorbidities that may interfere with study assessments. * History of malignancy, including mycosis fungoides, within 5 years before the screening visit, except completely treated in situ carcinoma of the cervix, completely treated and resolved non-metastatic squamous or basal cell carcinoma of the skin. * Severe concomitant illness(es) that in the Investigator's judgment would adversely affect the patient's participation in the study. Any other medical or psychological condition that in the opinion of the Investigator may suggest a new and/or insufficiently understood disease, may present an unreasonable risk to the study patient because of his/her participation in this clinical trial, may make patient's participation unreliable, or may interfere with study assessments. 20. Pregnant or breastfeeding women, or women planning to become pregnant or breastfeed during the study.

Inclusion Criteria

Exclusion Criteria

* Established diagnosis of AD for at least 1 year before the screening visit and topical treatment was inadequate or inadvisable.
* Moderate-to-severe AD with involvement \> 10% of body-surface-area (BSA) and investigator global assessment (IGA) score =3 (based on the IGA scale ranging from 0 to 4, in which 3 is moderate and 4 is severe) at both the screening and baseline visits.
* Subject has an Eczema Area and Severity Index (EASI) score =16 at screening and baseline.
* Subject has a pruritus NRS =4.
* Subject is biologic naïve.
* Female subjects of childbearing potential (i.e., fertile, following menarche and until becoming post-menopausal unless permanently sterile) must agree either to commit to true abstinence throughout the study and for at least 17 weeks after the last study drug (SD) injection, when this is in line with the preferred and usual lifestyle of the subject, or to use a highly-effective and approved method of contraception throughout the study and for at least 17 weeks after the last study drug injection.
* Subject willing and able to comply with all of the clinical study protocol's time commitments and procedural requirements.
* Understand and sign an informed consent form (ICF) (and assent form, when applicable) before any investigational procedure(s) are performed.

* Previous treatment with lebrikizumab or participation in a lebrikizumab study.
* History of anaphylaxis as defined by the Sampson criteria.
* Treatment with topical corticosteroids, calcineurin inhibitors, Jak inhibitors, or crisaborole within 1 week prior to the baseline visit.
* Prior treatment with dupilumab or tralokinumab.
* Treatment with any of the following agents within 4 weeks prior to the baseline visit:
1. Immunosuppressive/immunomodulating drugs (e.g., systemic corticosteroids, cyclosporine, mycophenolate-mofetil, IFN-., Janus kinase inhibitors (JAKi), azathioprine, methotrexate).
2. Phototherapy and photochemotherapy (PUVA) for AD.
* Treatment with the following prior to the baseline visit:
1. An investigational drug within 8 weeks or 5 half-lives (if known), whichever is longer.
2. Cell-depleting biologics, including to rituximab, within 6 months.
3. Other biologics within 5 half-lives (if known) or 16 weeks, whichever is longer.
* Use of prescription moisturizers within 7 days of the baseline visit.
* Regular use (more than 2 visits per week) of a tanning booth/parlor within 4 weeks of the screening visit.
* Treatment with a live (attenuated) vaccine within 12 weeks of the baseline visit or planned during the study.
* Uncontrolled chronic disease that might require bursts of oral corticosteroids, e.g., co-morbid severe uncontrolled asthma requiring systemic \[oral and/or parenteral\] corticosteroid treatment or hospitalization for \> 24 hours).
* Active chronic or acute infection requiring treatment with systemic antibiotics, antivirals, anti-parasitics, antiprotozoals, or antifungals within 2 weeks before the baseline visit, or superficial skin infections within 1 week before the baseline visit. NOTE: patients may be rescreened after infection resolves.
* Evidence of active acute or chronic hepatitis (as defined by the Department of Health \& Human Services Centers for Disease Control and Prevention) or known liver cirrhosis.
* Diagnosed active endoparasitic infections or at high risk of these infections.
* Known or suspected history of immunosuppression, including history of invasive opportunistic infections (e.g., tuberculosis \[TB\], histoplasmosis, listeriosis, coccidioidomycosis, pneumocystosis, and aspergillosis) despite infection resolution: or unusually frequent, recurrent, or prolonged infections, per the Investigator's judgment.
* History of human immunodeficiency virus (HIV) infection or positive HIV serology at screening.
* In the Investigator's opinion, any clinically significant laboratory results from the chemistry, hematology or urinalysis tests available in the medical history.
* Presence of skin comorbidities that may interfere with study assessments.
* History of malignancy, including mycosis fungoides, within 5 years before the screening visit, except completely treated in situ carcinoma of the cervix, completely treated and resolved non-metastatic squamous or basal cell carcinoma of the skin.
* Severe concomitant illness(es) that in the Investigator's judgment would adversely affect the patient's participation in the study. Any other medical or psychological condition that in the opinion of the Investigator may suggest a new and/or insufficiently understood disease, may present an unreasonable risk to the study patient because of his/her participation in this clinical trial, may make patient's participation unreliable, or may interfere with study assessments.
20. Pregnant or breastfeeding women, or women planning to become pregnant or breastfeed during the study.

Contacts and Locations

Study Contact

Diane Fiolek

CONTACT

734-763-1469

dianemch@med.umich.edu

Principal Investigator

Johann E. Gudjonsson, MD, PhD

PRINCIPAL_INVESTIGATOR

University of Michigan

Study Locations (Sites)

Physioseq USA - CA

Folsom, California, 95630

United States

University of Michigan

Ann Arbor, Michigan, 48109

United States

Collaborators and Investigators

Sponsor: Johann E Gudjonsson MD PhD

Johann E. Gudjonsson, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07

Study Completion Date2027-06

Study Record Updates

Study Start Date2025-07

Study Completion Date2027-06

Terms related to this study

Additional Relevant MeSH Terms

Atopic Dermatitis