RECRUITING

Using Xe MRI to Guide Radiation Therapy for Lung Cancer

Description

The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.

Conditions

Imaging Techniques
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Imaging Techniques

Study Overview

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Study Details

Study overview

The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.

Image-Based Functionally Adapted Radiation Therapy for Lung Cancer

Using Xe MRI to Guide Radiation Therapy for Lung Cancer

Condition
Imaging Techniques
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Aged 18-80 years
  • 2. Willing and able to provide informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.)
  • 3. Clinical diagnosis of lung cancer made by a board-certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease with the exception of the below criteria
  • 1. Subject is less than 18 years old or incarcerated
  • 2. MRI is contraindicated based on responses to MRI screening questionnaire
  • 3. Subject is pregnant or lactating
  • 4. Resting oxygen saturation \<90% on supplemental oxygen
  • 5. Respiratory illness of bacterial or viral etiology within 30 days of planned treatment
  • 6. Subject has history of any known ventricular cardiac arrhythmia
  • 7. Subject has history of cardiac arrest within the last year
  • 8. Subject has prior history of cancer treatment with radiation therapy to the lung
  • 9. Subject has concurrent cancer treatment with agents associated with increased risk of radiation pneumonitis (e.g. immunotherapy, chemotherapy)
  • 10. Subject does not fit into 129Xe vest coil used for MRI
  • 11. Subject cannot hold his/her breath for 15 seconds
  • 12. Subject deemed unlikely to be able to comply with instructions during imaging
  • 13. Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Sean Fain,

Sean Fain, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

2027-01