RECRUITING

Evaluation of the Antioxidant and Anti-Inflammatory Capacities of the 'Rosy Red Valencia' and 'Olinda Valencia' Sweet Orange Varieties in Healthy Subjects

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to evaluate the antioxidant and anti-inflammatory effects of acute and chronic consumption of two sweet orange (Citrus sinensis) varieties-'Rosy Red Valencia', which is rich in carotenoids such as lycopene, phytoene, and phytofluene, and 'Olinda Valencia', which lacks these carotenoids-in healthy adults. In this 4-week, randomized, parallel-arm clinical trial, participants will consume either 'Rosy Red Valencia' or 'Olinda Valencia' oranges daily. The study will assess the effects of sweet orange intake on markers of oxidative stress and inflammation, plasma carotenoid concentrations, gene expression in peripheral blood mononuclear cells, and gut health. Findings from this study may help identify potential health benefits associated with specific carotenoid profiles in sweet oranges and provide insights into their role in modulating inflammation and oxidative stress.

Official Title

Evaluation of the Antioxidant and Anti-Inflammatory Capacities of the 'Rosy Red Valencia' and 'Olinda Valencia' Sweet Orange Varieties in Healthy Subjects

Quick Facts

Study Start:2025-04-17
Study Completion:2026-01-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06944210

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:25 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. * Pregnancy/lactation
  2. * History of cardiovascular diseases, diabetes, uncontrolled hypertension, heart failure, stroke, liver, gallbladder, kidney, thyroid disease, gastrointestinal, autoimmune disorder, or cancer.
  3. * Psychiatric disease that interferes with the understanding and implementation of the intervention
  4. * History of eating disorders (such as bulimia nervosa and anorexia nervosa) in the last 5 years
  5. * Current smokers
  6. * Vegan, vegetarian, or other special diets (e.g., keto, paleo)
  7. * Use of antibiotics or laxatives in the previous month
  8. * History of substance abuse or alcohol abuse
  9. * involvement in a weight loss intervention program within the past month or weight change \> 10%
  10. * Self-report of allergic reactions to study products or their phytochemicals.

Contacts and Locations

Study Contact

Irena Krga, PhD
CONTACT
+1530-752-6554‬
ikrga@ucdavis.edu

Principal Investigator

Gerardo G Macknezie, PhD
STUDY_DIRECTOR
Univeristy of California Davis

Study Locations (Sites)

Nutrition Department, Ragle Facility, University of California Davis
Davis, California, 95616
United States

Collaborators and Investigators

Sponsor: University of California, Davis

  • Gerardo G Macknezie, PhD, STUDY_DIRECTOR, Univeristy of California Davis

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-17
Study Completion Date2026-01-30

Study Record Updates

Study Start Date2025-04-17
Study Completion Date2026-01-30

Terms related to this study

Keywords Provided by Researchers

  • Oranges
  • Lycopene
  • Healthy
  • Oxidative stress
  • Inflammation
  • gene expression

Additional Relevant MeSH Terms

  • Healthy