RECRUITING

A Phase 2 Study of the Safety and Efficacy of Brepocitinib in Adults With Cutaneous Sarcoidosis (BEACON)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with cutaneous sarcoidosis.

Official Title

A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Investigate the Safety and Efficacy of Oral Brepocitinib in Adults With Cutaneous Sarcoidosis

Quick Facts

Study Start:2025-04-09
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06978725

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Adults subjects (18-74)
  2. 2. Cutaneous sarcoidosis with characteristic skin biopsy histology
  3. 3. A CSAMI activity score ≥ 10
  4. 4. Weight \> 40 kg to \< 130 kg with BMI \< 40 kg/m2 .
  5. 1. History of
  6. * Lymphoproliferative disorder
  7. * Active malignancy;
  8. * History of cancer within 5 years prior to baseline (exceptions for basal cell carcinoma, squamous cell carcinoma, or carcinoma in situ of the uterine cervix).
  9. 2. High risk of thrombosis or cardiovascular disease
  10. 3. High risk of herpes zoster
  11. 4. Active or recent infection
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Clinical Trial Administrator
CONTACT
(212) 634-9743
clinicaltrials@priovant.com

Study Locations (Sites)

Clinical Trial Site
San Francisco, California, 94115
United States
Clinical Trial Site
Durham, North Carolina, 27703
United States
Clinical Trial Site
Philadelphia, Pennsylvania, 19104
United States
Clinical Trial Site
Madison, Wisconsin, 53715
United States

Collaborators and Investigators

Sponsor: Priovant Therapeutics, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-09
Study Completion Date2026-12

Study Record Updates

Study Start Date2025-04-09
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • sarcoidosis
  • cutaneous sarcoidosis
  • brepocitinib

Additional Relevant MeSH Terms

  • Cutaneous Sarcoidosis