Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * Weight of at least 40 kg
- * On a stable prescribed standard of care (SoC) treatment regimen according to local guidelines and the specific requirements for each disease
- * Systolic blood pressure ≤160 mmHg and diastolic blood pressure ≤90 mmHg at Screening. For participants aged ≥10 to \<18 years, the average of 3 separate systolic and/or diastolic blood pressures \<95th percentile for age, gender, and height
- * Age ≥ 10 years
- * Biopsy proven IgAN or IgAVN,
- * UPCR ≥ 0.5 g/g
- * eGFR≥ 20 mL/min/1.73m2
- * Age ≥ 18 years
- * Biopsy-proven pMN
- * Anti PLA2R antibodies ≥ 25 RU/mL
- * UPCR ≥ 1.5 g/g
- * At low risk for spontaneous remission (based on severity or duration of disease)
- * Age ≥ 10 years
- * eGFR≥30 mL/min/1.73m2
- * Biopsy diagnosis of primary MCD or FSGS (adults) or challenging clinical course with steroids in children (frequenlty relapsing, steroid-dependent, or steroid-resistant)
- * UPCR ≥ 1.0 g/g at Screening,
- * Evidence of anti-nephrin antibodies
- * Evidence of rapidly progressive glomerulonephritis (loss of ≥50% of eGFR) within 3 months prior to and at Screening)
- * Active viral or bacterial infections
- * Existing conditions or clinically significant laboratory abnormalities that may interfere with participation in this study
- * Administration of live and live-attenuated vaccinations within 30 days prior to enrollment
- * Known hypersensitivity to atacicept or any component of the formulated atacicept
- * Additional criteria apply to each cohort/disease.
Ages Eligible for Study
10 Years to
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No