RECRUITING

A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes

Description

The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes. Participants will be screened for about 4 weeks, after which they will enroll into either J2A-MC-GZP1, NCT06972459 (do not have type 2 diabetes) or J2A-MC-GZP2, NCT06972472 (have type 2 diabetes).

Study Overview

Study Details

Study overview

The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes. Participants will be screened for about 4 weeks, after which they will enroll into either J2A-MC-GZP1, NCT06972459 (do not have type 2 diabetes) or J2A-MC-GZP2, NCT06972472 (have type 2 diabetes).

A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes

A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Tucson

Novak Clinical Research - Tucson - North La Cholla Boulevard, Tucson, Arizona, United States, 85741

San Ramon

Norcal Endocrinology & Internal Medicine, San Ramon, California, United States, 94583

Santa Ana

Southern California Clinical Research, Santa Ana, California, United States, 92701

Thousand Oaks

Care Access - Thousand Oaks, Thousand Oaks, California, United States, 91360

DeLand

Accel Research Sites - DeLand Clinical Research Unit, DeLand, Florida, United States, 32720

Fort Lauderdale

Innovation Medical Research Center - Fort Lauderdale, Fort Lauderdale, Florida, United States, 33316

Hollywood

Encore Medical Research, Hollywood, Florida, United States, 33024

Ocoee

West Orange Endocrinology P.A., Ocoee, Florida, United States, 34761

Tampa

Care Access - Tampa, Tampa, Florida, United States, 33625

Decatur

Care Access - Decatur, Decatur, Georgia, United States, 30030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Eli Lilly and Company,

    Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST), STUDY_DIRECTOR, Eli Lilly and Company

    Study Record Dates

    2027-08