RECRUITING

Mood Effects of Serotonin Agonists: Depression

Description

This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.

Conditions

LSDMajor Depressive DisorderDepression
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Related Conditions:

LSDMajor Depressive DisorderDepression

Study Overview

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Study Details

Study overview

This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.

Mood Effects of Serotonin Agonists: Depression

Mood Effects of Serotonin Agonists: Depression

Condition
LSD
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Chicago, Chicago, Illinois, United States, 60637

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English Fluency
  • * high school education or higher
  • * BMI between 19-30 kg/m2
  • * individuals with a medical condition contraindicating study participation as determined by the study physician (e.g., liver disease, abnormal EKG, liver or cardiovascular disease)
  • * high blood pressure (\>140/90)
  • * current suicidal ideation or suicide attempt in past 12 months
  • * past year severe substance use disorder
  • * personal or first-degree relative with history of psychosis
  • * currently taking any psychiatric medication (for conventional antidepressants must be off for ≥ 2 weeks)
  • * active panic disorder
  • * severe obsessive-compulsive disorder
  • * severe post-traumatic stress disorder
  • * women who are pregnant or planning to become pregnant

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Chicago,

Hanna Molla, PRINCIPAL_INVESTIGATOR, University of Chicago

Study Record Dates

2026-06-01