RECRUITING

Olfactory Biopsies

Description

This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell. The purpose of this study is to collect tissue from the nasal cavity.

Conditions

Alzheimer DiseaseSmell LossSmell Dysfunction
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Related Conditions:

Alzheimer DiseaseSmell LossSmell Dysfunction

Study Overview

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Study Details

Study overview

This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell. The purpose of this study is to collect tissue from the nasal cavity.

Analysis of Human Olfactory Biopsies

Olfactory Biopsies

Condition
Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

Durham

Duke University Health Center, Durham, North Carolina, United States, 27710

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Between the ages of 18 and 80
  • * Pre-clinical AD (this cohort consists of subjects who have normal cognitive testing and function, but have positive AD biomarkers);
  • * Symptomatic AD (a confirmed diagnosis of Alzheimer's or dementia who are capable of understanding and signing the consent document)
  • * Advanced Alzheimer's/dementia
  • * Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
  • * Active Rhinosinusitis symptoms
  • * Other known sinonasal disease history that would preclude biopsy (i.e prior sinus or skull base surgery directly impacting this anatomic region, sinonasal neoplasm in this anatomic region, olfactory cleft polyps)
  • * Parkinson's disease
  • * Unable or willing to complete the nasal endoscopy procedure.
  • * Unable to read or speak English
  • * Unable to provide legally effective consent

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Duke University,

Bradley Goldstein, MD, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2028-12-31