High Intensity Resistance Training + Creatine in Perimenopause

Eligibility Criteria

• * Women transitioning through perimenopause (defined by the North American Menopause Society Menopause Health Questionnaire), with or without hormone therapy or experiencing two or more perimenopause-related symptoms, as determined from the validated North American Menopause Society
• * Women ≥38-60 yrs.
• * Recreationally active \[(≥30 minutes of moderate-intensity physical activity per week and \<3 times per week of progressive resistance training, as defined by the International Physical Activity Questionnaire (IPAQ)\]
• * Body mass index of 18.5-34.9 kg/m\^2
• * Is at risk or has a current chronic disease that is not contraindicated by exercise, and could be improved by resistance exercise (i.e. type 2 diabetes, heart disease, hypertension, hypercholesterolemia, hyperthyroidism, depression, osteoporosis, etc.)
• * Experienced a musculoskeletal injury within the past three months that inhibits participation in the study.
• * Has chronic kidney disease, liver disease, chronic obstructive pulmonary disease, or cancer
• * Currently using medications that may directly impact the primary outcomes including: diuretics and corticosteroids).
• * Currently using creatine monohydrate or other performance-enhancing supplements
• * Has a self-identified or clinically diagnosed eating disorder
• * Currently pregnant or planning to become pregnant (determined from urine pregnancy test)
• * Currently nursing or have had a child within the previous 6 months
• * Has participated in another clinical trial within four weeks prior to enrollment that in the opinion of the PI would influence the results.
• * Has severely impaired hearing or speech or inability to speak English.
• * Unwilling or unable to comply with the study protocol, including abstaining from caffeine, tobacco, alcohol, and physical activity before testing days.