RECRUITING

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Description

The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.

Study Overview

Study Details

Study overview

The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Chandler

MD First Research - Chandler, Chandler, Arizona, United States, 85286

Tucson

Tucson Orthopaedic Institute - North Wyatt Drive, Tucson, Arizona, United States, 85712

Fountain Valley

Ark Clinical Research - Fountain Valley, Fountain Valley, California, United States, 92708

Fullerton

St Joseph Heritage Healthcare, Fullerton, California, United States, 92835

Los Angeles

Clinical Research Institute, Los Angeles, California, United States, 90048

San Diego

Artemis Institute for Clinical Research, San Diego, California, United States, 92103

Boulder

Alpine Clinical Research Center, Boulder, Colorado, United States, 80301

Daytona Beach

K2 Medical Research - Daytona Beach, Daytona Beach, Florida, United States, 32114

Miami

Suncoast Research Group, Miami, Florida, United States, 33135

Saint Petersburg

IMA Clinical Research St. Petersburg, Saint Petersburg, Florida, United States, 33704

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Have a history of axial-predominant low back pain
  • * Have pain that is restricted to the low back or with a referral pattern limited to the proximal legs
  • * Have a body mass index (BMI) ≥27 kilograms per square meter (kg/m2) at screening
  • * Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight
  • * Have a non-axial origin low back pain
  • * Have had botulinum or steroid injections to the spine within 1 year of screening
  • * Have had trigger point injection to the spine within 6 months of screening
  • * Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days prior to screening
  • * Have been taking drugs to promote body weight reduction, including over-the-counter medications, within 90 days prior to screening
  • * Have a prior or planned surgical treatment for obesity
  • * Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Eli Lilly and Company,

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST), STUDY_DIRECTOR, Eli Lilly and Company

Study Record Dates

2027-09