RECRUITING

Evaluation of Ketamine/Midazolam Deep Sedation vs. Fentanyl/Midazolam Moderate Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

Description

This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.

Study Overview

Study Details

Study overview

This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.

Prospective Single-Blinded Randomized Study of Ketamine/Midazolam Deep Sedation vs. Fentanyl/Midazolam Moderate Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

Evaluation of Ketamine/Midazolam Deep Sedation vs. Fentanyl/Midazolam Moderate Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

Condition
Sedation
Intervention / Treatment

-

Contacts and Locations

Charleston

CAMC Memorial, Charleston, West Virginia, United States, 25304

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Planned to undergo image-guided bone biopsy, lung biopsy, or percutaneous drainage
  • * Eligible to receive ketamine or fentanyl sedation
  • * Any sex/gender, any race
  • * Aged 18-89
  • * Pregnant/lactating
  • * Incarceration
  • * Currently taking an opioid agonist/antagonist
  • * Food consumed in past 6-8 hours
  • * Allergies to drugs used in the study
  • * Lacks mental capacity for reporting pain scores
  • * Hypotension or respiratory failure precluding fentanyl sedation
  • * Uncontrolled hypertension precluding ketamine sedation
  • * Condition for which hypertension would be a concern
  • * Schizophrenia

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

CAMC Health System,

Amy R Deipolyi, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, CAMC Department of Interventional Radiology

Study Record Dates

2026-06-30