RECRUITING

Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

Description

After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).

Conditions

Phantom Pain Following Amputation of Lower LimbAmputation
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Related Conditions:

Phantom Pain Following Amputation of Lower LimbAmputation

Study Overview

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Study Details

Study overview

After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).

Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

Condition
Phantom Pain Following Amputation of Lower Limb
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Jefferson Moss Rehabilitation Research Institute, Philadelphia, Pennsylvania, United States, 19027

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19122

Seattle

University of Washington, Seattle, Washington, United States, 98195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18 -100
  • * Capacity to provide Informed Consent
  • * Unilateral above or below knee amputation more than 3 months prior to enrollment
  • * Absence of cognitive impairment, operationally defined as a Montreal Cognitive Assessment score of 18 or greater1.
  • * Pain averaged over the preceding 1 month in the phantom limb rated as greater than 4 on a scale of 0-10.
  • * History of significant medical or neurological disorder such as stroke or moderate to severe traumatic brain injury (operationally defined as loss of consciousness for more than 30 minutes)
  • * History of significant or poorly controlled psychiatric disorders
  • * Substantial depression or anxiety affecting their ability to perform tasks necessary for the study.
  • * Current abuse of alcohol or drugs, prescription or otherwise
  • * Nursing a child, pregnant, or intent to become pregnant during the study

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Albert Einstein Healthcare Network,

Study Record Dates

2025-08-30