RECRUITING

Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).

Official Title

Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

Quick Facts

Study Start:2025-06-16
Study Completion:2025-08-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07044323

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 -100
  2. * Capacity to provide Informed Consent
  3. * Unilateral above or below knee amputation more than 3 months prior to enrollment
  4. * Absence of cognitive impairment, operationally defined as a Montreal Cognitive Assessment score of 18 or greater1.
  5. * Pain averaged over the preceding 1 month in the phantom limb rated as greater than 4 on a scale of 0-10.
  1. * History of significant medical or neurological disorder such as stroke or moderate to severe traumatic brain injury (operationally defined as loss of consciousness for more than 30 minutes)
  2. * History of significant or poorly controlled psychiatric disorders
  3. * Substantial depression or anxiety affecting their ability to perform tasks necessary for the study.
  4. * Current abuse of alcohol or drugs, prescription or otherwise
  5. * Nursing a child, pregnant, or intent to become pregnant during the study

Contacts and Locations

Study Contact

Laurel Buxbaum
CONTACT
215-663-6321
Laurel.Buxbaum@jefferson.edu

Study Locations (Sites)

Jefferson Moss Rehabilitation Research Institute
Philadelphia, Pennsylvania, 19027
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19122
United States
University of Washington
Seattle, Washington, 98195
United States

Collaborators and Investigators

Sponsor: Albert Einstein Healthcare Network

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-16
Study Completion Date2025-08-30

Study Record Updates

Study Start Date2025-06-16
Study Completion Date2025-08-30

Terms related to this study

Keywords Provided by Researchers

  • pain
  • phantom limb
  • lower limb amputation
  • treatment

Additional Relevant MeSH Terms

  • Phantom Pain Following Amputation of Lower Limb
  • Amputation