RECRUITING

The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity

Description

This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.

Study Overview

Study Details

Study overview

This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.

The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity

The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity

Condition
Chronic Kidney Disease
Intervention / Treatment

-

Contacts and Locations

Jackson

University of Mississippi Medical Center, Jackson, Mississippi, United States, 39216

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults 18-75 years old
  • * Normal kidney function
  • * No heart failure
  • * BMI 25-30kg/m2
  • * Diagnosis of chronic illness
  • * eGFR\<60mL/min/1.73m2
  • * Pregnancy or breast feeding
  • * History of cutaneous or allergic reaction to iodine-based products of contrast dyes
  • * Hemoglobin levels \<7mg/dL
  • * Acute illness or hospitalization event within 3 months
  • * Unable to stop NSAIDs
  • * Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
  • * Current use of nicotine or recreational drugs, chronic drinker

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Mississippi Medical Center,

Marissa C Tio, MD, PRINCIPAL_INVESTIGATOR, University of Mississippi Medical Center

Study Record Dates

2026-07-31