RECRUITING

Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

Description

This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without stimulation. DBS parameters would be adjusted prior to motor testing. Patients would then participate in multiple sessions performing contralateral upper extremity movement tasks measuring movement speed, grip strength, and strength modulation, facial movement, swallowing, and speech tasks.

Conditions

Traumatic Brain InjuryStrokeBrain DiseaseMovement Disorders (Incl Parkinsonism)Central Nervous System DiseaseEssential Tremor, Movement DisordersEssential Tremor of Voice
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Related Conditions:

Traumatic Brain InjuryStrokeBrain DiseaseMovement Disorders (Incl Parkinsonism)Central Nervous System DiseaseEssential Tremor, Movement DisordersEssential Tremor of Voice

Study Overview

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Study Details

Study overview

This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without stimulation. DBS parameters would be adjusted prior to motor testing. Patients would then participate in multiple sessions performing contralateral upper extremity movement tasks measuring movement speed, grip strength, and strength modulation, facial movement, swallowing, and speech tasks.

Chronic Stimulation of the Motor Ventral Thalamus (VOP/VIM) for Motor Control in Humans

Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

Condition
Traumatic Brain Injury
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age lower than 80 to better tolerate intraoperative testing.
  • * All Movement disorder patients, older than 18 and younger than 80, who will be implanted with DBS for treatment of motor symptoms.
  • * Subject has provided written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization, where applicable, prior to any study-related procedures.
  • * Subject is ≥18 years of age and \< 80 years of age.
  • * Subject is willing and able to comply with scheduled visits and study procedures.
  • * Patients will be excluded from the study if there is any seizure history, to avoid the increased epileptogenic risk during stimulation testing.
  • * Patients with bilateral tremors will be excluded.
  • * Patients with vasovagal response history and loss of consciousness history will be excluded.
  • * Subject has severe behavioral or cognitive problems that preclude participation in the study, in the opinion of the investigator would impact participation in the study.
  • * Participants who have any serious disease or disorder (e.g. cancer, severe cardiac or respiratory disease, neurological conditions other than stroke, etc.) or cognitive impairments that could affect their ability to participate in this study.
  • * Female subjects are pregnant or breastfeeding.

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Pittsburgh,

Jorge Gonzalez-Martinez, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2030-12-31