RECRUITING

A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.

Official Title

A Double-Blinded Prospective Randomized Clinical Trial Comparing Euploidy Rates Among Embryos Created From Sibling Oocytes Exposed to Sperm After Ultrashort Abstinence Compared With Standard Abstinence

Quick Facts

Study Start:2025-07
Study Completion:2027-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07062237

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 42 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Subjects are nonpregnant females ≥ 18 years and ≤ 42 years of age.
  2. * Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination.
  3. * Subjects are utilizing standard insemination or ICSI for fertilization.
  4. * Subjects are undergoing PGT-A (PGT for aneuploidy) or PGT-M (PGT for monogenic disorders).
  5. * Subjects are willing to comply with study protocol and procedures and provide written informed consent.
  1. * Subjects are utilizing donor oocytes, donor sperm, or gestational carrier.
  2. * Subjects have a diagnosis of cryptozoospermia (no spermatozoa identified in fresh semen sample).
  3. * Subjects are utilizing surgically removed sperm (e.g. via testicular sperm aspiration \[TESA\] or microsurgical epididymal sperm aspiration \[MESA\]).
  4. * Subjects are utilizing frozen/thawed sperm, including in cases in which a fresh sample was planned and the sample is insufficient for use.
  5. * Subjects are utilizing frozen/thawed oocytes.
  6. * Subjects undergoing PGT-SR (PGT for structural rearrangements).
  7. * Subjects are undergoing a day 3 (cleavage stage) embryo transfer.
  8. * Subjects obtain less than 6 mature oocytes at the time of oocyte retrieval for ICSI or less than 8 oocytes at the time of oocyte retrieval for standard insemination.
  9. * Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination but choose to fertilize fewer than 6 (for ICSI) or 8 (for standard insemination).
  10. * Male partner is unable to produce a second semen sample within three hours of the first semen sample (standard abstinence sample)
  11. * Male partner has an infectious disease.

Contacts and Locations

Study Locations (Sites)

The Center for Advanced Reproductive Services, P.C.
Farmington, Connecticut, 06032
United States

Collaborators and Investigators

Sponsor: UConn Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07
Study Completion Date2027-06

Study Record Updates

Study Start Date2025-07
Study Completion Date2027-06

Terms related to this study

Keywords Provided by Researchers

  • Ultrashort abstinence
  • Sibling oocyte
  • In vitro fertilization
  • Euploid embryos

Additional Relevant MeSH Terms

  • Infertility
  • Male Factor Infertility