RECRUITING

A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence

Description

This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.

Conditions

InfertilityMale Factor Infertility
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Related Conditions:

InfertilityMale Factor Infertility

Study Overview

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Study Details

Study overview

This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.

A Double-Blinded Prospective Randomized Clinical Trial Comparing Euploidy Rates Among Embryos Created From Sibling Oocytes Exposed to Sperm After Ultrashort Abstinence Compared With Standard Abstinence

A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence

Condition
Infertility
Intervention / Treatment

-

Contacts and Locations

Farmington

The Center for Advanced Reproductive Services, P.C., Farmington, Connecticut, United States, 06032

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects are nonpregnant females ≥ 18 years and ≤ 42 years of age.
  • * Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination.
  • * Subjects are utilizing standard insemination or ICSI for fertilization.
  • * Subjects are undergoing PGT-A (PGT for aneuploidy) or PGT-M (PGT for monogenic disorders).
  • * Subjects are willing to comply with study protocol and procedures and provide written informed consent.
  • * Subjects are utilizing donor oocytes, donor sperm, or gestational carrier.
  • * Subjects have a diagnosis of cryptozoospermia (no spermatozoa identified in fresh semen sample).
  • * Subjects are utilizing surgically removed sperm (e.g. via testicular sperm aspiration \[TESA\] or microsurgical epididymal sperm aspiration \[MESA\]).
  • * Subjects are utilizing frozen/thawed sperm, including in cases in which a fresh sample was planned and the sample is insufficient for use.
  • * Subjects are utilizing frozen/thawed oocytes.
  • * Subjects undergoing PGT-SR (PGT for structural rearrangements).
  • * Subjects are undergoing a day 3 (cleavage stage) embryo transfer.
  • * Subjects obtain less than 6 mature oocytes at the time of oocyte retrieval for ICSI or less than 8 oocytes at the time of oocyte retrieval for standard insemination.
  • * Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination but choose to fertilize fewer than 6 (for ICSI) or 8 (for standard insemination).
  • * Male partner is unable to produce a second semen sample within three hours of the first semen sample (standard abstinence sample)
  • * Male partner has an infectious disease.

Ages Eligible for Study

18 Years to 42 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

UConn Health,

Study Record Dates

2027-06