RECRUITING

Investigating the Safety and Efficacy of the 1927-nm Thulium Laser in Keratosis Pilaris

Description

Keratosis pilaris (KP) is a very common skin condition that affects up to 80% of adolescents and 40% of adults. Clinically, KP causes rough dry patches and tiny spiny bumps around the hair follicles, as well as redness and pigmentation changes, most often on the upper arms, thighs, cheeks, or buttocks. While KP is benign, it can be cosmetically very bothersome. Currently, treatment options for KP are limited, and consist of topical moisturizers and keratolytic agents, but often leads to suboptimal improvements. In literature, many laser treatment modalities for KP have been studied, with varying results. The primary aim of this pilot study is to investigate how KP, a predominantly follicular disorder, responds to treatment with the 1927-nm Thulium laser.

Conditions

Keratosis Pilaris (KP)
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Related Conditions:

Keratosis Pilaris (KP)

Study Overview

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Study Details

Study overview

Keratosis pilaris (KP) is a very common skin condition that affects up to 80% of adolescents and 40% of adults. Clinically, KP causes rough dry patches and tiny spiny bumps around the hair follicles, as well as redness and pigmentation changes, most often on the upper arms, thighs, cheeks, or buttocks. While KP is benign, it can be cosmetically very bothersome. Currently, treatment options for KP are limited, and consist of topical moisturizers and keratolytic agents, but often leads to suboptimal improvements. In literature, many laser treatment modalities for KP have been studied, with varying results. The primary aim of this pilot study is to investigate how KP, a predominantly follicular disorder, responds to treatment with the 1927-nm Thulium laser.

Investigating the Safety and Efficacy of the 1927-nm Thulium Laser for Soft Tissue Coagulation in Keratosis Pilaris

Investigating the Safety and Efficacy of the 1927-nm Thulium Laser in Keratosis Pilaris

Condition
Keratosis Pilaris (KP)
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins University, Baltimore, Maryland, United States, 21287

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female or male, in good health, ages 18-65
  • * Voluntarily signed informed consent form
  • * Any Fitzpatrick skin type (I-VI)
  • * Clinically diagnosed keratosis pilaris of bilateral upper arms
  • * Willing to have photographs taken and agree to the use of photographs for regulatory, presentation, or marketing purposes
  • * Willing and able to follow protocol procedures and requirements
  • * History of receiving any laser therapy to the bilateral arms in the 12 months before recruitment
  • * History of or concurrent use of radiation to the bilateral arms in the 12 months before recruitment
  • * Participation of other device or drug clinical trials within 1 month before recruitment
  • * Concurrent diagnosis of active skin condition in the arms
  • * Presence of an active systemic or local skin disease that may affect wound healing
  • * History of forming keloids, collagen vascular disease, chronic drug or alcohol use
  • * History of malignant tumors in the upper arms
  • * Presence of open ulcers or infections any skin site
  • * Presence of a tan or sunburn over the upper arms in the month before recruitment
  • * Use of topical or oral photosensitizing medications
  • * Excessive body hair or tattoo in target area
  • * Pregnant and/or breastfeeding
  • * Presence of any medical conditions that interfere with subject's participation
  • * History of diagnosed pigmentary disorders in the target area
  • * Current smoker or history of smoking within 5 years

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Sarah Hsu, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Myriam Gonzalez, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2026-12