Treatment Trials

2 Clinical Trials for Various Conditions

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      TERMINATED
      INSIGHT-AHP: A Study to Characterize the Prevalence of Acute Hepatic Porphyria (AHP) in Patients With Clinical Presentation and History Consistent With AHP
      Description

      This study will use specific diagnostic tests on a group of patients who are experiencing symptoms typical of acute hepatic porphyria (AHP) to determine how many have the condition, and to potentially help improve the diagnostic process for patients in the future.

      Conditions
      Acute Hepatic PorphyriaHepatic PorphyriasAcute Intermittent Porphyria (AIP)Hereditary Coproporphyria (HCP)Variegate Porphyria (VP)ALA Dehydratase Deficient Porphyria (ADP)Porphyria Acute
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      COMPLETED
      ENVISION: A Study to Evaluate the Efficacy and Safety of Givosiran (ALN-AS1) in Patients With Acute Hepatic Porphyrias (AHP)
      Description

      The purpose of this study is to evaluate the effect of subcutaneous givosiran (ALN-AS1), compared to placebo, on the rate of porphyria attacks in patients with Acute Hepatic Porphyrias (AHP).

      Conditions
      Acute Hepatic PorphyriaAcute Intermittent PorphyriaPorphyria, Acute IntermittentAcute PorphyriaHereditary Coproporphyria (HCP)Variegate Porphyria (VP)ALA Dehydratase Deficient Porphyria (ADP)
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