14 Clinical Trials for Various Conditions
Alaska Native children experience a high burden of respiratory disease, especially those in the Yukon-Kuskokwim (YK) Delta. Studies have shown that things like wood stove use, poor ventilation, and indoor tobacco smoke exposure can lead to poor indoor air quality inside the children's homes. This leads to more frequent and more severe respiratory infections in children. In the Yukon-Kuskokwim (YK) Delta, it's common for homes to have exposure to woodstoves and tobacco use. Both of these activities affect indoor air quality in homes. We know that high efficiency particulate air (HEPA) purifiers can reduce particulate matter and make air quality better. One way that we measure air quality is through particulate matter (PM2.5). One of the few studies that looked at this in the YK Delta found that PM2.5 levels that were nearly twice as high as homes with woodstoves in other states. We believe it is important to reduce the PM2.5 in YK Delta homes. However, the few studies that looked at HEPA purifiers in rural Alaska did not include homes where smokers lived. We know that breathing air with PM2.5 harms the lungs. We also know that HEPA filters can reduce PM2.5, which can mean reducing cough and wheeze in people with chronic lung conditions. We want to learn how HEPA filters work in homes with woodstoves or where a smoker lives, as it's likely these homes may have more PM2.5 than other homes. We expect that using HEPA filters will make the indoor air better and will mean decreased respiratory symptoms. We plan to include 15 households with a child less than 5 years old in the family. Households that join will be asked to: * Set up study equipment in their homes. * Run the study equipment for 12 weeks and do a weekly report of child's respiratory symptoms by phone or text. * Return the air-quality monitor equipment to the study team and keep the HEPA filters.
The purpose of this study is to determine the effectiveness of different sales offers and different marketing messages to increase the uptake of energy efficient cookstoves. This research will address the following major barriers to the acquisition and correct use of improved cookstoves into four main categories: * Inappropriate product or marketing for intended users * Lack of consumer trust in new products * Failure to address consumers' financial constraints * Failure to achieve behavioral change To do so this research includes 3 Randomized Controlled Trials including:RCT 1- Testing the Effectiveness of Marketing Messages in Increasing Willingness to Pay; RCT 2- Testing the Effectiveness of the Novel Sales Offer and its ability to Increase Uptake of Purchasing Energy Efficient Cookstoves; and RCT 3-Measure the Effects of Fuel Efficient Cookstoves on Health, Fuel Use and Time Spent Collecting Fuel. RCT 1 studies the price women are willing to pay for the improved stove. It will also test the effects of the two most effective marketing messages identified during the Phase 1 Feasibility stage (e.g., improved health, saves time, and has high status) on increasing willingness to pay. RCT 1 will run second price auctions in 36 parishes with an average of 60 participants per meeting. From RCT 1, RCT 2 tests the effect of a Novel Sales Offer- which includes a free trial, and time payments- on purchasing decisions of participants versus those that receive the Traditional Offer- a cash and carry offer. Based on a pilot in urban Kampala conducted by Dr. David I. Levine (co-P.I. on this project) results show a 44% uptake for households offered the novel offer vs. a 4% uptake for those offered the traditional offer. The hypothesis is a novel offer will significantly increase uptake of fuel efficient cookstoves in rural Uganda when compared to a traditional offer. RCT 3 measures the impacts of fuel efficient cookstoves on health, fuel usage, and time spent collecting fuel. For RCT 3 we will randomize those who accept the Novel Offer into early and late groups. To measure the impacts of improved stoves on health, fuel use, time spent collecting fuel, etc., there will be a baseline and follow-up survey and associated quantitative measures on our full sample and a small endline on select quantitative measures for a sub-sample.
The aims of this project are twofold: 1. to characterize indoor air quality components obtained from apartments with gas stoves and open kitchens in a cohort of Black adults with uncontrolled asthma recruited from federally qualified health centers and enrolled in the parent study. 2. to conduct a comprehensive assessment of feasibility, implementation, and acceptability of the study.
This pilot study (n=20) is a prospective evaluation of the implementation of an indoor air pollution intervention among adults 55 years of age or older. The intervention, called Air Improvement and Real-time Monitoring for Wellness through Interactive Strategies and Education (AIRWISE), is focused on improving indoor air quality through air filtration, education, and behavioral recommendations. All participants will receive the AIRWISE intervention with the objective of evaluating acceptance and use of the individual intervention components. This implementation study will inform the submission of a larger NIH proposal for a randomized trial. The central study hypothesis is that an intervention program with educational strategies and visual behavioral cues will increase knowledge and awareness of air pollution exposures among the participants and lead to improved intervention compliance.
This study evaluates the impact of a solar lighting system on kerosene lamp use, levels of indoor air pollution, and health in women living in rural Uganda. Half of the participants will receive the lighting systems immediately, while the other half will receive them after an 18 month delay.
Primary objective of this project is to measure the impact of passive control and active control systems on indoor pollution that is directly or indirectly related to ambient air pollution (smog). The first goal will be to measure baseline parameters for 50 homes, including information about the building, ventilation characteristics, pollution levels (indoors and outdoors), and occupant survey information. In a subset of these homes, either passive or active control systems will be installed and the impact of these systems on indoor concentrations. Participants will be enrolled on a rolling basis (5-15 persons studied at a given point in time) over a 16-month period. Participants will be followed for approximately 5 weeks and data obtained at three points in time: at enrollment (day 1 of study), after 1 week (baseline verification) and after four weeks with the control system in the home (at the end of study week 5).
The purpose of this study is to determine whether reducing indoor exposure to NO2 and particles improves respiratory health in children with asthma.
This study is about asthma and how the environment affects asthma. Scientists know that air pollution (such as cigarette smoke and other particles in the air) can make asthma symptoms worse. This research is being done to study how the health of a person with asthma responds to an air cleaner. The investigator hypothesize that an air cleaner will improve the health of persons with asthma.
The goal of this study was to investigate the effectiveness of three common approaches to upgrading residential mechanical ventilation systems in existing homes for improving asthma-related health outcomes, reducing indoor pollutants of both indoor and outdoor origin, and maintaining adequate environmental conditions and ventilation rates in a cohort of adult asthmatics in existing homes in Chicago, IL.
The investigators propose a pilot trial of kitchen ventilation in the homes of children using a youth engaged research strategy.
The goal of this clinical trial is to learn about whether indoor air quality will improve over time in homes where occupants receive personalized information about levels of health-relevant air pollutants that includes practical, budget-friendly, and culturally relevant recommendations on actions they can take to improve their home's air quality. The rationale for the investigators' approach is that a rigorous intervention study design will generate robust evidence on the value of the in-home environmental data. Participating homes in both the intervention and control groups will receive three, one-week Home Health Box deployments spaced six weeks apart. After each of the first two deployments, homes in the intervention group will receive a Home Health Report with personalized information about in-home levels of health-relevant air pollutants and cost-sensitive recommendations on actions occupants can take to improve their home's air quality. The investigators will (a) investigate whether and how air quality changes over time in control and intervention homes and (b) survey intervention households on the utility of the Home Health Reports.
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
The goal of this clinical trial is to compare indoor air quality and health in people exposed to air pollution, including possible exposure to wildfire smoke. The study will test the effect of using a do-it-yourself (DIY) air cleaner when air pollution is present to answer the following questions: * Do health outcomes differ between participants who use a DIY PAC and those who use a sham air cleaner? * How effective is the DIY air cleaner in reducing indoor concentrations of fine particles (PM2.5), and volatile organic compounds found in wildfire smoke? OR How effective is the DIY air cleaner in reducing indoor concentrations of fine and coarse particles (i.e., PM 10)? * What are barriers to use of a DIY air cleaner and what factors facilitate its use? Participants will be asked to do the following: * Participate in 5 home visits from study staff between July - October 2023 * Have an air quality sensor placed in the participant's bedroom for the whole study period * Have a small sensor attached to the main door of the participant's house to record when the door is open or closed (important for air quality inside) * Allow researchers to take air and dust samples in the participant's bedroom * Run a DIY air cleaner in the participant's bedroom for at least 6 nights while the participant sleeps * Complete 2 interviews * Allow study staff to collect 3 fingerstick blood samples * Allow study staff to collect 3 samples of fluid from inside the nose * Use the study air cleaner in the participant's bedroom during the study period The investigators will measure air quality in participating homes and measure health outcomes for participants. The investigators will compare outcomes of participants who use a DIY air cleaner with filters that work well to those of participants who use a DIY air cleaner with a placebo filter (one that does not work well to remove the air pollutants of concern). The goal of the study is to see if using the effective air cleaner leads to better health outcomes and indoor air quality.
This CTSI pilot study will assess for benefit of a community health worker or nursing student taught green cleaning curriculum (developed by the local asthma coalition) provided to Milwaukee County day care staff. Consumer grade indoor air quality monitors will be deployed before and after the educational intervention to objectively monitor changes as a result of the intervention. Surveys regarding changes in cleaning practices by day care staff will also be obtained to assess changes resulting from the intervention.