Treatment Trials

3 Clinical Trials for Various Conditions

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      COMPLETED
      A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification
      Description

      The primary objective of the current study is to determine whether Ataciguat (HMR1766) slows progression of valve calcification in patients with moderate calcific aortic valve stenosis. Secondary and tertiary objectives are to determine whether Ataciguat slows progression of aortic valve function, reduces systemic inflammation, and prevents left ventricular dysfunction in patients with moderate calcific aortic valve stenosis.

      Conditions
      Aortic Valve Stenosis
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      ACTIVE_NOT_RECRUITING
      Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study
      Description

      To evaluate the safety and feasibility of DurAVR™ THV System in the treatment of subjects with symptomatic severe native aortic stenosis.

      Conditions
      Aortic StenosisSymptomatic Aortic StenosisSevere Aortic Valve StenosisAortic Valve Calcification
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      ACTIVE_NOT_RECRUITING
      Identification of Genetic Causes of Calcific Aortic Valve Disease
      Description

      This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.

      Conditions
      Calcific Aortic StenosisCalcific Aortic Stenosis - Bicuspid ValveAortic Valve DiseaseAortic Valve CalcificationAortic DiseasesAortic AneurysmAortic Valve Cusp AbnormalityAortic Valve Disease MixedAortic Valve Insufficiency
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