Treatment Trials

3 Clinical Trials for Various Conditions

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COMPLETED
A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification
Description

The primary objective of the current study is to determine whether Ataciguat (HMR1766) slows progression of valve calcification in patients with moderate calcific aortic valve stenosis. Secondary and tertiary objectives are to determine whether Ataciguat slows progression of aortic valve function, reduces systemic inflammation, and prevents left ventricular dysfunction in patients with moderate calcific aortic valve stenosis.

ACTIVE_NOT_RECRUITING
Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study
Description

To evaluate the safety and feasibility of DurAVR™ THV System in the treatment of subjects with symptomatic severe native aortic stenosis.

ACTIVE_NOT_RECRUITING
Identification of Genetic Causes of Calcific Aortic Valve Disease
Description

This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.