Treatment Trials

3 Clinical Trials for Various Conditions

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      NO_LONGER_AVAILABLE
      Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access
      Description

      Expanded access to DCA as continued treatment for congenital lactic acidosis.

      Conditions
      Mitochondrial Enzyme Deficiencies
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      COMPLETED
      Pharmacotoxicology of Trichloroethylene Metabolites
      Description

      To establish the relationship between human MAAI haplotype and DCA and tyrosine metabolism. This aim test the postulates that MAAI haplotype determines, and thus can predict,1) dose-dependent DCA kinetics and biotransformation.

      Conditions
      Congenital Lactic Acidosis
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      COMPLETED
      Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia
      Description

      OBJECTIVES: I. Determine the pharmacokinetics of sodium dichloroacetate (DCA) in patients with congenital lactic acidemia. II. Determine the efficacy of DCA in decreasing the frequency and/or severity of acute episodes of acidotic illness, improving linear growth, improving neurological or developmental function, or slowing neurological or developmental deterioration in these patients.

      Conditions
      Lactic Acidosis
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