Treatment Trials

2 Clinical Trials for Various Conditions

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      TERMINATED
      Effects of Evolocumab on Platelet Reactivity in Patients With Diabetes Mellitus
      Description

      Prospective, single center, double-blind, randomized pharmacodynamic experimental study. The study will enroll 150 subjects with ASCVD on optimal statin therapy as per physician and Diabetes Mellitus (DM) undergoing elective Percutaneous Coronary Intervention (PCI). Eligible patients will be randomized for 30 day treatment to either 1) evolocumab 420 mg ; or 2) placebo.

      Conditions
      Diabetes Mellitus, Type 2Dyslipidemia Associated With Type II Diabetes MellitusPercutaneous Coronary Intervention
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      COMPLETED
      Effect of Insulin Sensitizer Therapy on Atherothrombotic and Inflammatory Profiles Associated With Insulin Resistance
      Description

      The objective of this study is to determine whether targeted pharmacological improvement of insulin sensitivity will normalize the associated elevations of thrombotic and inflammatory cardiovascular disease (CVD) biomarkers in individuals with insulin resistance.

      Conditions
      Type 2 DiabetesInsulin ResistanceMetabolic Syndrome
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