Treatment Trials

3 Clinical Trials for Various Conditions

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      COMPLETED
      Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients
      Description

      This study will evaluate zoledronic acid's anti-cancer effects and Circulating Tumor Cell (CTCs) measurements in patients with HER2-negative metastatic breast cancer without bone metastasis.

      Conditions
      First or Second Line HER2-negative Breast CancerMetastatic Disease Without Bone Metastasis
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      NOT_YET_RECRUITING
      Prospective Registry of ADC as First- and Second-line Treatment for Breast Cancer
      Description

      Antibody-drug conjugates (ADCs) have demonstrated substantial improvement in progression free survival (PFS) and overall survival (OS) in phase III clinical trials in patients with metastatic triple negative breast cancer (mTNBC) and hormone receptor positive/HER2 negative (HR+/HER2-) metastatic breast cancer (MBC), offering an effective new treatment strategy. Several outstanding questions drive the decision to use ADC drugs clinically. This is a prospective, multi-site observational study of patients with metastatic breast cancer (mBC) who are being treated with FDA-approved antibody drug conjugates (ADCs) as part of routine care and aims to collect real-world data to evaluate the impact of ADC treatment as part of routine care.

      Conditions
      HER2-negative Breast CancerHER2 Negative Breast CarcinomaMetastatic Breast CancerHR+ HER2 Breast CancerMetastatic Triple Negative Breast CancersMetastatic Triple-Negative Breast Carcinoma
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      COMPLETED
      Randomized Phase II Trial of Letrozole With or Without Dasatinib as First and Second-line Treatment for Hormone Receptor-positive, HER2-negative Post-menopausal Breast Cancer That is Unresectable, Locally Recurrent or Metastatic
      Description

      The purpose of this study is to find out what effect the combination of letrozole (brand name: Femara) and dasatinib (brand name: Sprycel) has on metastatic breast cancer compared to letrozole alone

      Conditions
      Metastatic Breast Cancer
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